Benzenesulfinamide, 4-chloro-

Base Information

• Chemical Name: Benzenesulfinamide, 4-chloro-
• CAS No.: 16096-86-9
• Molecular Formula: C6H6ClNOS
• Molecular Weight: 175.639
• Mol file: 16096-86-9.mol

Synonyms:

Chemical Property of Benzenesulfinamide, 4-chloro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenesulfinamide, 4-chloro-

There total 8 articles about Benzenesulfinamide, 4-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methyl p-chlorobenzenesulphinate (26760-21-4) → p-chlorobenzenesulphinamide (16096-86-9)

Guidance literature:

methyl p-chlorobenzenesulphinate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

With ammonium chloride; In tetrahydrofuran; for 1h;

DOI:10.1016/j.tetlet.2018.10.038

Reference yield: 73.0%

p-Chlorothiophenol (106-54-7) → p-chlorobenzenesulphinamide (16096-86-9)

Guidance literature:

With methanol; [2,2]bipyridinyl; O-pivaloylhydroxylamine trifluoromethanesulfonate salt; iron(II) chloride; In dichloromethane; at 25 ℃; for 16h; Sealed tube;

DOI:10.1002/anie.202011138

Reference yield: 69.0%

sodium p-chlorobenzenesulphinate (14752-66-0) → p-chlorobenzenesulphinamide (16096-86-9)

Guidance literature:

sodium p-chlorobenzenesulphinate; With oxalyl dichloride; In toluene; at 0 - 20 ℃; for 1h;

With ammonium hydroxide; In toluene; at 0 - 20 ℃; for 1h;

DOI:10.1055/s-0037-1609320

upstream raw materials:

4-nitro-4’-chlorodiphenylsulfoxide

C₁₂H₉ClN₂O₃S

1-(4-chlorophenylthio)-4-nitrobenzene

p-Chlorothiophenol

Refernces

• 1、 Chatterjee, Sayanti,Makai, Szabolcs,Morandi, Bill. "Hydroxylamine-Derived Reagent as a Dual Oxidant and Amino Group Donor for the Iron-Catalyzed Preparation of Unprotected Sulfinamides from Thiols". supporting information. p. 758 - 765. Retrieved 2020/11/30.
• 2、 Ma, Long-jun,Li, Guang-xun,Huang, Jin,Zhu, Jin,Tang, Zhuo. "Synthesis of asymmetrical thioethers with sulfinamides as the sulfenylation agent under metal-free conditions". supporting information. p. 4255 - 4258. Retrieved 2018/10/31.