1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, methyl ester

Base Information

Chemical Name:1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, methyl ester
CAS No.:848086-72-6
Molecular Formula:C37H37ClF3NO3
Molecular Weight:636.154
Hs Code.:

1-Naphthalenecarboxylic acid,
5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino
]propoxy]-1,2,3,4-tetrahydro-, methyl ester

Synonyms:

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Chemical Property of 1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, methyl ester

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Technology Process of 1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, methyl ester

There total 7 articles about 1-Naphthalenecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1,2,3,4-tetrahydro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 848086-71-5
5-hydroxy-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester

: 612499-61-3
(3-bromopropyl)({ [2-chloro-3-(trifluoromethyl)phenyl]methyl})(2,2-diphenylethyl)amine

: 848086-72-6
5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester

Guidance literature:: With potassium carbonate; sodium iodide; In acetone;
DOI:10.1016/j.bmcl.2009.08.036

Reference yield:

: 93118-03-7
2-chloro-3-trifluoromethylbenzaldehyde

: 848086-72-6
5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 1.5 h / 20 °C

2: potassium carbonate / acetonitrile / 48 h / Heating / reflux

3: potassium carbonate; sodium iodide / acetonitrile / 16 h / Heating / reflux

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; sodium iodide; In dichloromethane; acetonitrile;

Reference yield:

: 405102-95-6
5-(benzyloxy)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

: 848086-72-6
5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 2 h / Heating / reflux

2: hydrogen / palladium on activated charcoal / methanol / 16 h

3: potassium carbonate; sodium iodide / acetonitrile / 16 h / Heating / reflux

With sulfuric acid; hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In methanol; acetonitrile;