1(2H)-Quinolinecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-3,4-dihydro-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1(2H)-Quinolinecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-3,4-dihydro-, 1,1-dimethylethyl ester
CAS No.:848086-74-8
Molecular Formula:C39H42ClF3N2O3
Molecular Weight:679.222
Hs Code.:

1(2H)-Quinolinecarboxylic acid,
5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino
]propoxy]-3,4-dihydro-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1(2H)-Quinolinecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-3,4-dihydro-, 1,1-dimethylethyl ester

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Technology Process of 1(2H)-Quinolinecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-3,4-dihydro-, 1,1-dimethylethyl ester

There total 3 articles about 1(2H)-Quinolinecarboxylic acid, 5-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-3,4-dihydro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 497068-73-2
tert-butyl 5-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate

: 612499-61-3
(3-bromopropyl)({ [2-chloro-3-(trifluoromethyl)phenyl]methyl})(2,2-diphenylethyl)amine

: 848086-74-8
5{3-[(chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-3,4-dihydro-2H-quinoline-1-carboxylic acid ter-butyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Heating / reflux;

Reference yield:

: 93118-03-7
2-chloro-3-trifluoromethylbenzaldehyde

: 848086-74-8
5{3-[(chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-3,4-dihydro-2H-quinoline-1-carboxylic acid ter-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 1.5 h / 20 °C

2: potassium carbonate / acetonitrile / 48 h / Heating / reflux

3: potassium carbonate / acetonitrile / 24 h / Heating / reflux

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 405911-35-5
N-(2,2-diphenylethyl)-N-(2-chloro-trifluoromethylbenzyl)amine

: 848086-74-8
5{3-[(chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-3,4-dihydro-2H-quinoline-1-carboxylic acid ter-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 48 h / Heating / reflux

2: potassium carbonate / acetonitrile / 24 h / Heating / reflux

With potassium carbonate; In acetonitrile;