Benzo[c]thiophen-4(5H)-one, 1-(4-cyclohexyl-4,5-dihydro-5-thioxo-1H-1,2,4-triazol-3-yl)-6,7-dihydro-3 -(methylthio)-

Base Information

• Chemical Name: Benzo[c]thiophen-4(5H)-one, 1-(4-cyclohexyl-4,5-dihydro-5-thioxo-1H-1,2,4-triazol-3-yl)-6,7-dihydro-3 -(methylthio)-
• CAS No.: 848127-22-0
• Molecular Formula: C₁₇H₂₁N₃OS₃
• Molecular Weight: 379.571
• Mol file: 848127-22-0.mol

Synonyms:

Chemical Property of Benzo[c]thiophen-4(5H)-one, 1-(4-cyclohexyl-4,5-dihydro-5-thioxo-1H-1,2,4-triazol-3-yl)-6,7-dihydro-3 -(methylthio)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzo[c]thiophen-4(5H)-one, 1-(4-cyclohexyl-4,5-dihydro-5-thioxo-1H-1,2,4-triazol-3-yl)-6,7-dihydro-3 -(methylthio)-

There total 3 articles about Benzo[c]thiophen-4(5H)-one, 1-(4-cyclohexyl-4,5-dihydro-5-thioxo-1H-1,2,4-triazol-3-yl)-6,7-dihydro-3 -(methylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5,6,7-tetrahydro-3-methylthio-4-oxobenzo[c]thiophene-1-carboxylic Acid Ethyl Ester (168279-54-7) → 1-(4-cyclohexyl-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-3-methylsulfanyl-6,7-dihydro-5H-benzo[c]thiophen-4-one (848127-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₂NH₂*H₂O

2: alkaline aq. solution

3: aq. NaHCO₃

With sodium hydrogencarbonate; hydrazine hydrate; In alkaline aq. solution;

DOI:10.1016/j.bmcl.2004.12.039

Reference yield:

3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)one-1-carboxylic acid hydrazide (848127-18-4) → 1-(4-cyclohexyl-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-3-methylsulfanyl-6,7-dihydro-5H-benzo[c]thiophen-4-one (848127-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: alkaline aq. solution

2: aq. NaHCO₃

With sodium hydrogencarbonate; In alkaline aq. solution;

DOI:10.1016/j.bmcl.2004.12.039

Reference yield:

C17H23N3O2S3 → 1-(4-cyclohexyl-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-3-methylsulfanyl-6,7-dihydro-5H-benzo[c]thiophen-4-one (848127-22-0)

Guidance literature:

With sodium hydrogencarbonate;

DOI:10.1016/j.bmcl.2004.12.039

upstream raw materials:

4,5,6,7-tetrahydro-3-methylthio-4-oxobenzo[c]thiophene-1-carboxylic Acid Ethyl Ester

3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)one-1-carboxylic acid hydrazide