[1,2,4]Triazolo[1,5-a]pyridin-8-amine

Base Information

• Chemical Name: [1,2,4]Triazolo[1,5-a]pyridin-8-amine
• CAS No.: 31052-95-6
• Molecular Formula: C6H6 N4
• Molecular Weight: 134.14
• Hs Code.: 2933990090
• European Community (EC) Number: 869-299-0
• NSC Number: 116473
• DSSTox Substance ID: DTXSID70297521
• Nikkaji Number: J101.153G
• Wikidata: Q82038650
• Mol file: 31052-95-6.mol

Synonyms:[1,2,4]Triazolo[1,5-a]pyridin-8-amine;31052-95-6;8-Amino-[1,2,4]triazolo[1,5-a]pyridine;MFCD01316370;s-Triazolo[1,5-a]pyridine, 8-amino-;(1,2,4)Triazolo(1,5-a)pyridin-8-amine;NSC116473;s-Triazolo[1, 8-amino-;SCHEMBL398829;DTXSID70297521;BCP29831;AKOS005070234;3F-375S;NSC 116473;NSC-116473;SB15535;SY129600;[1,2,4]Triazolo[1,5-a]pyridin-8-ylamine;CS-0054401;FT-0680274;Triazoloapyridinamine;8-Amino-triazolpyridin;[1,2,4]Triazolo[1,5-a]pyridin-8-amine #;P10173;EN300-1592166;J-502703

Chemical Property of [1,2,4]Triazolo[1,5-a]pyridin-8-amine

Chemical Property:

• Melting Point: 103-106°
• Boiling Point: °Cat760mmHg
• PKA: 3.62±0.30(Predicted)
• Flash Point: °C
• PSA: 56.21000
• Density: 1.5g/cm³
• LogP: 0.89270
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 134.059246208
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

97% ^*data from raw suppliers

[1,2,4]triazolo[1,5-a]pyridin-8-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C(=NC=N2)C(=C1)N

Technology Process of [1,2,4]Triazolo[1,5-a]pyridin-8-amine

There total 1 articles about [1,2,4]Triazolo[1,5-a]pyridin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Hydrazino-3-nitropyridine (15367-16-5) → 8-Amino-1,2,4-triazolo<2,3-a>pyridine (31052-95-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / 2.5 h / 150 °C

2: 60 percent / std. aq. NaHCO₃ / 1.5 h / Ambient temperature

3: 87 percent / hydrogen / 10 percent Pd-C / ethanol / 1.5 h / 90 °C / 44130.5 Torr

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol;

Reference yield: 79.0%

8-Amino-1,2,4-triazolo<2,3-a>pyridine (31052-95-6) + 4-methoxyphenyl-acetic chloride (4693-91-8) → N-([1,2,4]triazolo[1,5-a]pyridin-8-yl)-2-(4-methoxyphenyl)acetamide (1340879-45-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm401356t

Reference yield:

8-Amino-1,2,4-triazolo<2,3-a>pyridine (31052-95-6) → 4-(2-([1,2,4]triazolo[1,5-a]pyridin-8-ylamino)ethyl)phenol (1569870-51-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / dichloromethane / 16 h / 0 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; boron tribromide; triethylamine; In dichloromethane;

DOI:10.1021/jm401356t

upstream raw materials:

2-Hydrazino-3-nitropyridine

Downstream raw materials:

N-(4-methoxyphenethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-amine

4-(2-([1,2,4]triazolo[1,5-a]pyridin-8-ylamino)ethyl)phenol

N-([1,2,4]triazolo[1,5-a]pyridin-8-yl)-2-(4-methoxyphenyl)acetamide

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