3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(4-methyl-1-piperazinyl)-4-oxo-

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(4-methyl-1-piperazinyl)-4-oxo-
CAS No.:75338-41-9
Molecular Formula:C₁₇H₁₉F₂N₃O₃
Molecular Weight:351.353
Hs Code.:
DSSTox Substance ID:DTXSID90226297
Nikkaji Number:J407.710E
Wikidata:Q83105663
ChEMBL ID:CHEMBL282867
Mol file:75338-41-9.mol

Synonyms:75338-41-9;3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(4-methyl-1-piperazinyl)-4-oxo-;1,4-Dihydro-6,8-difluoro-1-ethyl-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;1-Ethyl-6,8-difluoro-1,4-dihydro-7-(1-(4-methylpiperazinyl))-4-oxoquinoline-3-carboxylic acid;Oprea1_382189;SCHEMBL312380;CHEMBL282867;DTXSID90226297;LS-141571;6,8-Difluoro-1-ethyl-7-(4-methylpiperazino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;1-ethyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Suppliers and Price of 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(4-methyl-1-piperazinyl)-4-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(4-methyl-1-piperazinyl)-4-oxo-

Chemical Property:

Vapor Pressure:1.34E-11mmHg at 25°C
Boiling Point:519.1°Cat760mmHg
Flash Point:267.7°C
PSA：65.78000
Density:1.368g/cm³
LogP:1.75250
XLogP3:-0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:351.13944780
Heavy Atom Count:25
Complexity:578

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCN(CC3)C)F)C(=O)O

Technology Process of 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(4-methyl-1-piperazinyl)-4-oxo-

There total 6 articles about 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(4-methyl-1-piperazinyl)-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 109-01-3
1-methyl-piperazine

: 75338-42-0
1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

: 75338-41-9
8-fluoro-pefloxacin

Guidance literature:: In acetonitrile; at 90 ℃; for 7h;
DOI:10.1016/j.ejmech.2011.01.044

Reference yield:

: 100501-62-0
ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

: 75338-41-9
8-fluoro-pefloxacin

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / acetic acid / 2 h / Reflux

2: acetonitrile / 7 h / 90 °C

With hydrogenchloride; water; In acetic acid; acetonitrile;
DOI:10.1016/j.ejmech.2011.01.044

Reference yield:

: 79660-46-1
ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 75338-41-9
8-fluoro-pefloxacin

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 95 °C

2: hydrogenchloride; water / acetic acid / 2 h / Reflux

3: acetonitrile / 7 h / 90 °C

With hydrogenchloride; water; potassium carbonate; In acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2011.01.044