1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:75338-42-0
Molecular Formula:C12H8F3NO3
Molecular Weight:271.196
Hs Code.:2933499090
European Community (EC) Number:616-213-2
DSSTox Substance ID:DTXSID70431504
Nikkaji Number:J135.048J
Wikidata:Q72477574
ChEMBL ID:CHEMBL128961
Mol file:75338-42-0.mol

Synonyms:75338-42-0;1-ETHYL-6,7,8-TRIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID;1-ETHYL-6,7,8-TRIFLUORO-4-OXOQUINOLINE-3-CARBOXYLIC ACID;1-Ethy-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid;3-Quinolinecarboxylic acid, 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-;1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;1-ethyl-6,7,8-trifluoro-4-oxo-quinoline-3-carboxylic Acid;1-Ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;SCHEMBL500816;CHEMBL128961;DTXSID70431504;FKKUVCHFRDLBHN-UHFFFAOYSA-N;AKOS000279620;SB69383;AS-72448;CS-0326463;FT-0689225;D95756;A865704;ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;1-ethyl-1,4-dihydro-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylic acid;1-ethyl-1,4-dihydro-6,7,8-trifluoro-4-oxo-3-quinolinecarboxylic acid;1-Ethyl-4-oxo-6,7,8-trifluoro-1,4-dihydroquinoline-3-carboxylic acid;1-ethyl-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid;1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid;1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid;1-ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid;1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid;ethyl-6, 7, 8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;1-ETHYL-6,7,8-TRIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLICACID

Suppliers and Price of 1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 95+%
1g
$ 460.00

Chemenu
1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 95%
1g
$ 430.00

American Custom Chemicals Corporation
1-ETHYL-6,7,8-TRIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 95.00%
5MG
$ 501.46

Alichem
1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylicacid
100g
$ 386.64

Total 55 raw suppliers

Chemical Property of 1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:211-213 °C
Refractive Index:1.557
Boiling Point:401.703 °C at 760 mmHg
PKA:-0?+-.0.20(Predicted)
Flash Point:196.743 °C
PSA：59.30000
Density:1.527 g/cm³
LogP:2.13690
Storage Temp.:2-8°C
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:271.04562760
Heavy Atom Count:19
Complexity:440

Purity/Quality:

99% ^*data from raw suppliers

1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)F)F)C(=O)O
Uses 1-Ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid is an impurity of Lomefloxacin (L469415),?a fluorinated quinolone antibacterial and a DNA gyrase antagonist.

Technology Process of 1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 6 articles about 1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 100501-62-0
ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

: 75338-42-0
1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: With hydrogenchloride; water; In acetic acid; for 2h; Reflux;
DOI:10.1016/j.ejmech.2011.01.044

Reference yield:

: 79660-46-1
ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 75338-42-0
1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) K₂CO₃ / 1.) DMF

2: HCl / acetic acid / Heating

With hydrogenchloride; potassium carbonate; In acetic acid;
DOI:10.1021/jm00400a017

Reference yield:

: 3862-73-5
2,3,4-trifluoroaniline

: 75338-42-0
1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 2 h / 110 - 120 °C

2: diphenylether / 8 h / 250 °C

3: potassium carbonate / N,N-dimethyl-formamide / 10 h / 95 °C

4: hydrogenchloride; water / acetic acid / 2 h / Reflux

With hydrogenchloride; water; potassium carbonate; In diphenylether; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.01.044