2-Hexenoic acid, 5-hydroxy-6-(phenylmethoxy)-, ethyl ester, (2E,5R)-

Base Information

Chemical Name:2-Hexenoic acid, 5-hydroxy-6-(phenylmethoxy)-, ethyl ester, (2E,5R)-
CAS No.:848566-35-8
Molecular Formula:C15H20O4
Molecular Weight:264.321
Hs Code.:

Synonyms:

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Chemical Property of 2-Hexenoic acid, 5-hydroxy-6-(phenylmethoxy)-, ethyl ester, (2E,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-Hexenoic acid, 5-hydroxy-6-(phenylmethoxy)-, ethyl ester, (2E,5R)-

There total 4 articles about 2-Hexenoic acid, 5-hydroxy-6-(phenylmethoxy)-, ethyl ester, (2E,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144895-66-9
(E)-ethyl 3-((4S,5S)-5-((benzyloxy)methyl)-2-oxo-1,3-dioxolan-4-yl)acrylate

: 848566-35-8
(R,E)-ethyl 6-(benzyloxy)-5-hydroxyhex-2-enoate

Guidance literature:: With formic acid; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenylphosphine; In tetrahydrofuran; for 0.5h; Heating;
DOI:10.1021/ol050044i

Reference yield:

: 144895-69-2
(3E,4E)-ethyl 6-(benzyloxy)hexa-2,4-dienoate

: 848566-35-8
(R,E)-ethyl 6-(benzyloxy)-5-hydroxyhex-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: K₃Fe(CN)6; K₂CO₃; MeSO₂NH₂ / OsO₄; (DHQ)2PHAL / 2-methyl-propan-2-ol; H₂O / 0 - 20 °C

2: pyridine / CH₂Cl₂ / 1.5 h

3: triethylamine; HCO₂H / Pd₂(DBA)3*CHCl₃; triphenylphosphine / tetrahydrofuran / 0.5 h / Heating

With pyridine; formic acid; methanesulfonamide; potassium carbonate; triethylamine; potassium hexacyanoferrate(III); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; osmium(VIII) oxide; Hydroquinone 1,4-phthalazinediyl diether; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/ol050044i

Reference yield:

: 848566-19-8
(E,4S,5S)-ethyl 6-(benzyloxy)-4,5-dihydroxyhex-2-enoate

: 848566-35-8
(R,E)-ethyl 6-(benzyloxy)-5-hydroxyhex-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 1.5 h

2: triethylamine; HCO₂H / Pd₂(DBA)3*CHCl₃; triphenylphosphine / tetrahydrofuran / 0.5 h / Heating

With pyridine; formic acid; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol050044i