2-METHYL-2-CYCLOHEXEN-1-ONE

Base Information

• Chemical Name: 2-METHYL-2-CYCLOHEXEN-1-ONE
• CAS No.: 1121-18-2
• Molecular Formula: C7H10 O
• Molecular Weight: 110.156
• Hs Code.: 2914299000
• Mol file: 1121-18-2.mol

Synonyms:2-Methyl-2-cyclohexen-1-one;2-Methyl-2-cyclohexene-1-one; 2-Methyl-2-cyclohexenone;2-Methyl-3-oxocyclohexene; NSC 617615

Chemical Property of 2-METHYL-2-CYCLOHEXEN-1-ONE

Chemical Property:

• Vapor Pressure: 0.873mmHg at 25°C
• Refractive Index: n20/D1.487
• Boiling Point: 180.9°Cat760mmHg
• Flash Point: 66.7°C
• PSA: 17.07000
• Density: 0.964g/cm³
• LogP: 1.68570

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methyl-2-cyclohexen-1-one 90% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-2-CYCLOHEXEN-1-ONE

There total 116 articles about 2-METHYL-2-CYCLOHEXEN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-methyl-2-oxocyclohexanecarboxylic acid 2-propenyl ester (7770-41-4) → 2-methyl-2-cyclohexen-1-one (1121-18-2) + 2-methyl-2-allylcyclohexanone (16178-87-3) + 2-Methylcyclohexanone (583-60-8)

Guidance literature:

palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; In acetonitrile; for 4h; Yields of byproduct given; Heating;

DOI:10.1055/s-1987-28145

Reference yield: 65.0%

1-acetoxy-2-methylcyclohexene (1196-73-2) → 2-methyl-2-cyclohexen-1-one (1121-18-2) + 2,2'-Dimethyl-bicyclohexyl-3,3'-dione (137639-98-6) + 2-Methylcyclohexanone (583-60-8)

Guidance literature:

With tetraethylammonium tosylate; In acetic acid; Ambient temperature; electrolysis of other enol acetates, other electrodes, also with metal salt addition;

DOI:10.1246/cl.1991.1661

Reference yield: 54.0%

6-(1,3-dioxolan-2-yl)hexan-3-one N,N-dimethylhydrazone (121196-17-6) → 2-Ethylpyridine (100-71-0) + 2-methyl-2-cyclohexen-1-one (1121-18-2)

Guidance literature:

With acetic acid; for 10h; Heating;

upstream raw materials:

quinoline

2-chloro-2-methylcyclohexanone

tert.-butylhydroperoxide

1-methylcyclohex-1-ene

Downstream raw materials:

triethyl(2-methylcyclohex-1-enyloxy)silane

1,2-dimethylcyclohex-2-en-1-ol

(2-methyl-3-oxo-cyclohexyl)-phosphonic acid dimethyl ester

1-ethynyl-2-methyl-cyclohex-2-enol

Refernces

• 1、 Kumar, Anubhav,Mondal, Supratim,Banerjee, Shibdas. "Aqueous Microdroplets Capture Elusive Carbocations". . p. 2459 - 2463. Retrieved 2021.
• 2、 Butz,Davies,Gaddis. "-". . p. 122,127. Retrieved 1947.
• 3、 Blanco, Luis,Amice, Philippe,Conia, Jean-Marie. "Reaction of Chloromethylcarbene with Trimethylsilyl Enol Ethers; Conversion of Cycloalkanones into Higher α-Methylcycloalkenones". . p. 289 - 291. Retrieved 1981.
• 4、 El-Qisairi, Arab K,Qaseer, Hanan A. "Oxidation of ketone by palladium(II), α-hydroxyketone synthesis catalyzed by a bimetallic palladium(II) complex". . p. 50 - 55. Retrieved 2002.
• 5、 Tsuji, Jiro,Minami, Ichiro,Shimizu, Isao. "A NOVEL PALLADIUM-CATALYZED PREPARATIVE METHOD OF α,β-UNSATURATED KETONES AND ALDEHYDES FROM SATURATED KETONES AND ALDEHYDES VIA THEIR SILYL ENOL ETHERS". . p. 5635 - 5638. Retrieved 1983.
• 6、 Arata et al.. "-". . p. 1097,1098,1099. Retrieved 1975.
• 7、 Shimazaki, Makoto,Huang, Zhi-Hui,Goto, Mikiko,Suzuki, Noriko,Ohta, Akihiro. "Syntesis of 2-Cycloalken-1-ones". . p. 677 - 678. Retrieved 1990.
• 8、 Grieco et al.. "". . p. 7102. Retrieved 1976.
• 9、 Poock, Caroline,Kalesse, Markus. "Total Synthesis and Structure Revision of Halioxepine". . p. 1615 - 1619. Retrieved 2020/12/23.
• 10、 Zhang, Wuyuan,Fueyo, Elena Fernandez,Hollmann, Frank,Martin, Laura Leemans,Pesic, Milja,Wardenga, Rainer,H?hne, Matthias,Schmidt, Sandy. "Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization". supporting information. p. 80 - 84. Retrieved 2019/01/04.