N-(1-benzylpiperidin-4-yl)naphthalene-2-carboxamide

Base Information

• Chemical Name: N-(1-benzylpiperidin-4-yl)naphthalene-2-carboxamide
• CAS No.: 848576-43-2
• Molecular Formula: C₂₃H₂₄N₂O
• Molecular Weight: 344.456
• UNII: 56XB596P3V
• ChEMBL ID: CHEMBL228972
• Pharos Ligand ID: 3XTDHBXYSLRN
• Mol file: 848576-43-2.mol

Synonyms:N-(1-benzylpiperidin-4-yl)naphthalene-2-carboxamide;56XB596P3V;UNII-56XB596P3V;CHEMBL228972;848576-43-2;CHEMBL-228972;N-(1-(Phenylmethyl)-4-piperidinyl)-2-naphthalenecarboxamide;N-(1-(Phenylmethyl)piperidin-4-yl)naphthalene-2-carboxamide;2-Naphthalenecarboxamide, N-(1-(phenylmethyl)-4-piperidinyl)-;N-(1-benzylpiperidine-4-yl)-2-naphthamide;BDBM50203383;STK491618;AKOS003382305;CCG-300476;MCULE-1935524858;PD186723;N-(1-benzyl-4-piperidinyl)-2-naphthamide;N-(1-benzylpiperidin-4-yl)-2-naphthamide;Z32353863

Chemical Property of N-(1-benzylpiperidin-4-yl)naphthalene-2-carboxamide

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 344.188863393
• Heavy Atom Count: 26
• Complexity: 451

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCC1NC(=O)C2=CC3=CC=CC=C3C=C2)CC4=CC=CC=C4

Technology Process of N-(1-benzylpiperidin-4-yl)naphthalene-2-carboxamide

There total 1 articles about N-(1-benzylpiperidin-4-yl)naphthalene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-1-benzylpiperidine (50541-93-0) + 2-naphthaloyl chloride (2243-83-6) → naphthalene-2-carboxylic acid (1-benzyl-piperidin-4-yl)-amide (848576-43-2)

Guidance literature:

With triethylamine; In ethyl acetate;

DOI:10.1016/j.bmcl.2006.12.096 DOI:10.1016/j.bmcl.2006.12.106

Reference yield:

naphthalene-2-carboxylic acid (1-benzyl-piperidin-4-yl)-amide (848576-43-2) → naphthalene-2-carboxylic acid [1-(1-phenyl-ethyl)-piperidin-4-yl]-amide

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 20 °C / 7500.6 Torr

2: K₂CO₃ / dimethylformamide / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.12.096

Reference yield:

naphthalene-2-carboxylic acid (1-benzyl-piperidin-4-yl)-amide (848576-43-2) → naphthalene-2-carboxylic acid (1-phenethyl-piperidin-4-yl)-amide

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 20 °C / 7500.6 Torr

2: K₂CO₃ / dimethylformamide / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.12.096

upstream raw materials:

4-amino-1-benzylpiperidine

2-naphthaloyl chloride