tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate

Base Information

Chemical Name:tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate
CAS No.:848591-68-4
Molecular Formula:C18H26N2O2
Molecular Weight:302.417
Hs Code.:
Mol file:848591-68-4.mol

Synonyms:t-butyl 3-benzyl-3,6-diazabicyclo[3.2.1]octane-6-carboxylate;3-Benzyl-3,6-diaza-bicyclo[3.2.1]octane-6-carboxylic Acid Tert-Butyl Ester;

Suppliers and Price of tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl3-benzyl-3,6-diazabicyclo[3.2.1]octane-6-carboxylate 97%
1g
$ 455.00

Alichem
tert-Butyl3-benzyl-3,6-diazabicyclo[3.2.1]octane-6-carboxylate
1g
$ 486.85

Total 3 raw suppliers

Chemical Property of tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate

Chemical Property:

PSA：32.78000
LogP:3.00360

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-benzyl-3,6-diazabicyclo[3.2.1]octane-6-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate

There total 4 articles about tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 848591-67-3
tert-butyl 2,4-diformylpyrrolidine-1-carboxylate

: 100-46-9
benzylamine

: 848591-68-4
tert-butyl 3-benzyl-3,6-diazabicyclo[3.2.1]octane-6-carboxylate

Guidance literature:: tert-butyl 2,4-diformylpyrrolidine-1-carboxylate; benzylamine; With sodium cyanoborohydride; In methanol; H2O; at 0 - 20 ℃; for 24h;

In water; ethyl acetate; at 0 ℃;

Reference yield: 77.0%

: 100-46-9
benzylamine

: 188345-71-3
2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene

: 848591-68-4
tert-butyl 3-benzyl-3,6-diazabicyclo[3.2.1]octane-6-carboxylate

Guidance literature:: 2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene; With ozone; acetic acid; In dichloromethane; at -78 ℃;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃;

benzylamine; With sodium cyanoborohydride; In methanol; at 20 ℃; for 24h; Further stages.;
DOI:10.1021/jm070018l

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 848591-68-4
tert-butyl 3-benzyl-3,6-diazabicyclo[3.2.1]octane-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NH₄Cl / H₂O / 17 h / 20 °C

1.2: 45 percent / aq. NaOH / 7 h / 20 °C / pH 8

2.1: O₃; AcOH / CH₂Cl₂ / -78 °C

2.2: dimethyl sulfide / CH₂Cl₂ / -78 - 20 °C

2.3: 77 percent / NaCNBH₃ / methanol / 24 h / 20 °C

With ammonium chloride; ozone; acetic acid; In dichloromethane; water;
DOI:10.1021/jm070018l