3-Morpholin-4-ium-4-ylpropane-1-sulfonate

Base Information

• Chemical Name: 3-Morpholin-4-ium-4-ylpropane-1-sulfonate
• CAS No.: 1132-61-2
• Molecular Formula: C7H15NO4S
• Molecular Weight: 209.266
• Hs Code.: 29349990
• Mol file: 1132-61-2.mol

Synonyms:3-morpholin-4-ium-4-ylpropane-1-sulfonate;CHEBI:39076;3-(N-morpholiniumyl)propanesulfonate;AKOS015962108;3-(4-morpholin-4-iumyl)-1-propanesulfonate;A803035

Chemical Property of 3-Morpholin-4-ium-4-ylpropane-1-sulfonate

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 0Pa at 25℃
• Melting Point: 277-282 ºC
• Refractive Index: 1.512
• PKA: 7.2(at 25℃)
• Flash Point: 116 ºC
• PSA: 75.22000
• Density: 1.298 g/cm³
• LogP: 0.61520
• Storage Temp.: Store at RT.
• Solubility.: H2O: 1 M at 20 °C, clear
• Water Solubility.: 1000 g/L (20 ºC)
• XLogP3: -3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 209.07217913
• Heavy Atom Count: 13
• Complexity: 214

Purity/Quality:

99.0%-101% ^*data from raw suppliers

MOPS, 1.0M buffer soln., pH 8.0 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COCC[NH+]1CCCS(=O)(=O)[O-]
• Description: MOPS (3-morpholinopropanesulfonic acid) is a buffer introduced by Good et al. in the 1960s. It is a structural analog to MES. Its chemical structure contains a morpholine ring. HEPES is a similar pH buffering compound that contains a piperazine ring. With a pKa of 7.20, MOPS is an excellent buffer for many biological systems at near-neutral pH.It is used as a synthetic buffering agent below pH 7.5.
• Uses: 3-(N-Morpholino)propanesulfonic acid or MOPS due to its inert nature is a preferred and widely used buffer in many biochemical studies.MOPS has been used as:a cell culture additive component in lentiviral particle production.as a buffering agent in microbial growth medium and nuclei extraction buffer.as a component of Roswell Park Memorial Institute (RPMI) medium for diluting fungal inoculum.as a buffer in capillary-zone electrophoresis to test performance.for the dilution of proteins from algal samples. MOPS acts as a multi-purpose buffering agent used in various biological research. MOPS has been used as:a cell culture additive component in lentiviral particle productionas a buffering agent in microbial growth medium and nuclei extraction buffer

Technology Process of 3-Morpholin-4-ium-4-ylpropane-1-sulfonate

There total 2 articles about 3-Morpholin-4-ium-4-ylpropane-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

morpholine (110-91-8,99108-56-2) + 1,3-propanesultone (1120-71-4) → 3-(N-morpholino)propanesulfonic acid (1132-61-2)

Guidance literature:

In acetone; at 25 ℃; for 3.5h;

DOI:10.1080/00397910903470509

Reference yield:

→ 3-(N-morpholino)propanesulfonic acid (1132-61-2)

Guidance literature:

Reference yield:

3-(N-morpholino)propanesulfonic acid (1132-61-2) → 3-(morpholin-4-yl)propane-1-sulfonyl chloride hydrochloride (197891-91-1)

Guidance literature:

With thionyl chloride; In N-methyl-acetamide;

upstream raw materials:

morpholine

1,3-propanesultone

Downstream raw materials:

3-(morpholin-4-yl)propane-1-sulfonyl chloride hydrochloride