Benzene, 1-[[(1R)-1-[(1S)-2-[(1R,5R,6R)-6-(dimethoxymethyl)-2-methyl-5-(1-meth ylethyl)-2-cyclohexen-1-yl]-1-(methoxymethoxy)ethyl]-2-propenyl]oxy]-4- methoxy-

Base Information

• Chemical Name: Benzene, 1-[[(1R)-1-[(1S)-2-[(1R,5R,6R)-6-(dimethoxymethyl)-2-methyl-5-(1-meth ylethyl)-2-cyclohexen-1-yl]-1-(methoxymethoxy)ethyl]-2-propenyl]oxy]-4- methoxy-
• CAS No.: 848760-89-4
• Molecular Formula: C27H42O6
• Molecular Weight: 462.627

Synonyms:

Chemical Property of Benzene, 1-[[(1R)-1-[(1S)-2-[(1R,5R,6R)-6-(dimethoxymethyl)-2-methyl-5-(1-meth ylethyl)-2-cyclohexen-1-yl]-1-(methoxymethoxy)ethyl]-2-propenyl]oxy]-4- methoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-[[(1R)-1-[(1S)-2-[(1R,5R,6R)-6-(dimethoxymethyl)-2-methyl-5-(1-meth ylethyl)-2-cyclohexen-1-yl]-1-(methoxymethoxy)ethyl]-2-propenyl]oxy]-4- methoxy-

There total 3 articles about Benzene, 1-[[(1R)-1-[(1S)-2-[(1R,5R,6R)-6-(dimethoxymethyl)-2-methyl-5-(1-meth ylethyl)-2-cyclohexen-1-yl]-1-(methoxymethoxy)ethyl]-2-propenyl]oxy]-4- methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2S,3R)-1-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]3-(4-methoxyphenoxy)-pent-4-en-2-ol (848760-88-3) + chloromethyl methyl ether (107-30-2) → 1-{(R)-1-[(S)-2-((1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl)-1-methoxymethoxy-ethyl]-allyloxy}-4-methoxybenzene (848760-89-4)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 7h;

DOI:10.1016/j.tet.2004.12.039

Reference yield:

allyl (4-methoxyphenyl) ether (13391-35-0) → 1-{(R)-1-[(S)-2-((1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl)-1-methoxymethoxy-ethyl]-allyloxy}-4-methoxybenzene (848760-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sec-BuLi / cyclohexane; tetrahydrofuran / -78 °C

1.2: [TiCl(Cp){(S,S)-Taddol}] / tetrahydrofuran; cyclohexane / -78 °C

1.3: 73 percent / tetrahydrofuran; cyclohexane; diethyl ether / -78 - 20 °C

2.1: 95 percent / DIPEA; TBAI / CH₂Cl₂ / 25 °C

With sec.-butyllithium; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; cyclohexane; 1.3: Hafner-Duthaler oxyallylation;

DOI:10.1002/chem.200500749

Reference yield:

[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]-acetaldehyde (221290-57-9) → 1-{(R)-1-[(S)-2-((1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl)-1-methoxymethoxy-ethyl]-allyloxy}-4-methoxybenzene (848760-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sec-BuLi / cyclohexane; tetrahydrofuran / -78 °C

1.2: [TiCl(Cp){(S,S)-Taddol}] / tetrahydrofuran; cyclohexane / -78 °C

1.3: 73 percent / tetrahydrofuran; cyclohexane; diethyl ether / -78 - 20 °C

2.1: 95 percent / DIPEA; TBAI / CH₂Cl₂ / 25 °C

With sec.-butyllithium; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; cyclohexane; 1.3: Hafner-Duthaler oxyallylation;

DOI:10.1002/chem.200500749

upstream raw materials:

(2S,3R)-1-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]3-(4-methoxyphenoxy)-pent-4-en-2-ol

chloromethyl methyl ether

allyl (4-methoxyphenyl) ether

[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]-acetaldehyde

Downstream raw materials:

2,2-dimethyl-propionic acid (1S,2R)-1-{(1R,5R,6R)-6-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-pent-4-enyl]-5-isopropyl-2-methyl-cyclohex-2-enylmethyl}-2-(4-methoxyphenoxy)-but-3-enyl ester

2,2-dimethyl-propionic acid (Z)-(1R,4aR,6S,7R,11S,12aR)-11-(tert-butyl-diphenylsilanyloxy)-1-isopropyl-7-(4-methoxyphenoxy)-4-methyl-1,2,4a,5,6,7,10,11,12,12a-decahydro-benzocyclodecen-6-yl ester

(2S,3R)-1-{(1R,5R,6R)-6-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-pent-4-enyl]-5-isopropyl-2-methyl-cyclohex-2-enyl}-3-(4-methoxyphenoxy)-pent-4-en-2-ol

2,2-dimethyl-propionic acid (1S,2R)-1-{(1R,5R,6R)-6-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-pent-4-enyl]-5-isopropyl-2-methyl-cyclohex-2-enylmethyl}-2-hydroxy-but-3-enyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 848760-89-4 Benzene, 1-[[(1R)-1-[(1S)-2-[(1R,5R,6R)-6-(dimethoxymethyl)-2-methyl-5-(1-meth ylethyl)-2-cyclohexen-1-yl]-1-(methoxymethoxy)ethyl]-2-propenyl]oxy]-4- methoxy-

Send

Send

Metric Ton KG G Pound L ML

Send

Send