L-Phenylalanine, N-[1-oxo-5-(phenylmethoxy)pentyl]-, methyl ester

Base Information

Chemical Name:L-Phenylalanine, N-[1-oxo-5-(phenylmethoxy)pentyl]-, methyl ester
CAS No.:848780-55-2
Molecular Formula:C22H27NO4
Molecular Weight:369.461
Hs Code.:

Synonyms:

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Chemical Property of L-Phenylalanine, N-[1-oxo-5-(phenylmethoxy)pentyl]-, methyl ester

Chemical Property:

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Technology Process of L-Phenylalanine, N-[1-oxo-5-(phenylmethoxy)pentyl]-, methyl ester

There total 6 articles about L-Phenylalanine, N-[1-oxo-5-(phenylmethoxy)pentyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64740-39-2
5-benzyloxypentanoic acid

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 848780-55-2
N-(5-benzyloxypentanoyl)-(S)-phenylalanine methyl ester

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.tet.2004.12.009

Reference yield:

: 111-29-5
1 ,5-pentanediol

: 848780-55-2
N-(5-benzyloxypentanoyl)-(S)-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / 15-crown-5; NaOH / tetrahydrofuran / 4 h / 10 °C

2: pyridine*SO₃; triethylamine; DMSO / CH₂Cl₂ / 0.33 h / 0 °C

3: NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 1 h / 0 °C

4: 3.73 g / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 3 h / 0 - 20 °C

With sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 15-crown-5; diethyl cyanophosphonate; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 2: Parikh-Doering oxidation;
DOI:10.1016/j.tet.2004.12.009

Reference yield:

: 4541-15-5
5-(benzyloxy)-1-pentanol

: 848780-55-2
N-(5-benzyloxypentanoyl)-(S)-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine*SO₃; triethylamine; DMSO / CH₂Cl₂ / 0.33 h / 0 °C

2: NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 1 h / 0 °C

3: 3.73 g / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 3 h / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diethyl cyanophosphonate; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Parikh-Doering oxidation;
DOI:10.1016/j.tet.2004.12.009