5-phenyl-3-(phenylcarbonyl)isoxazolo[4,3-d]pyrimidin-7(4H)-one

Base Information

• Chemical Name: 5-phenyl-3-(phenylcarbonyl)isoxazolo[4,3-d]pyrimidin-7(4H)-one
• CAS No.: 159850-74-5
• Molecular Formula: C₁₈H₁₁N₃O₃
• Molecular Weight: 317.304
• Mol file: 159850-74-5.mol

Synonyms:Isoxazolo[4,3-d]pyrimidin-7(4H)-one,3-benzoyl-5-phenyl- (9CI)

Chemical Property of 5-phenyl-3-(phenylcarbonyl)isoxazolo[4,3-d]pyrimidin-7(4H)-one

Chemical Property:

• Vapor Pressure: 1.86E-13mmHg at 25°C
• Boiling Point: 580.2°Cat760mmHg
• Flash Point: 304.7°C
• Density: 1.41g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-phenyl-3-(phenylcarbonyl)isoxazolo[4,3-d]pyrimidin-7(4H)-one

There total 1 articles about 5-phenyl-3-(phenylcarbonyl)isoxazolo[4,3-d]pyrimidin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-5-benzoylisoxazole-3-carboxamide (76390-64-2) + benzoic acid (65-85-0,8013-63-6) → 3-benzoyl-5-phenyl-7-oxo-6,7-dihydroisoxazolo<4,3-d>pyrimidine (159850-74-5)

Guidance literature:

With ethyl phosphate; Yield given. Multistep reaction; 1.) 100 deg C, 2 h, 2.) CHCl₃, reflux, 10 h;

Reference yield: 76.0%

3-benzoyl-5-phenyl-7-oxo-6,7-dihydroisoxazolo<4,3-d>pyrimidine (159850-74-5) → 3-benzoyl-5-phenyl-7-chloroisoxazolo<4,3-d>pyrimidine (166274-26-6)

Guidance literature:

With N,N-diethylaniline; trichlorophosphate; for 15h; Heating;

Reference yield:

3-benzoyl-5-phenyl-7-oxo-6,7-dihydroisoxazolo<4,3-d>pyrimidine (159850-74-5) → [7-(4-Methyl-piperazin-1-yl)-5-phenyl-isoxazolo[4,3-d]pyrimidin-3-yl]-phenyl-methanone

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / POCl₃, diethyl aniline / 15 h / Heating

2: 65 percent / K₂CO₃ / toluene / 16 h / Heating

With potassium carbonate; N,N-diethylaniline; trichlorophosphate; In toluene;

upstream raw materials:

4-amino-5-benzoylisoxazole-3-carboxamide

benzoic acid

Downstream raw materials:

3-benzoyl-5-phenyl-7-chloroisoxazolo<4,3-d>pyrimidine