Technology Process of Silane,
(1,1-dimethylethyl)dimethyl[(2S)-3-methyl-2-[(phenylmethyl)thio]butoxy]-
There total 5 articles about Silane,
(1,1-dimethylethyl)dimethyl[(2S)-3-methyl-2-[(phenylmethyl)thio]butoxy]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent Spectr. / (S)-2-{[3,5-(CF3)2C6H3]2(TMSO)C}pyrrolidine / toluene / 3 h / 20 °C
2: NaBH4 / toluene; methanol / 0.33 h / 20 °C
3: CH2Cl2
With
(S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; sodium tetrahydroborate;
In
methanol; dichloromethane; toluene;
DOI:10.1002/anie.200462101
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sulfuryl chloride / CH2Cl2 / 0.25 h
2: NEt3 / CH2Cl2
3: 90 percent Spectr. / (S)-2-{[3,5-(CF3)2C6H3]2(TMSO)C}pyrrolidine / toluene / 3 h / 20 °C
4: NaBH4 / toluene; methanol / 0.33 h / 20 °C
5: CH2Cl2
With
(S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; sodium tetrahydroborate; sulfuryl dichloride; triethylamine;
In
methanol; dichloromethane; toluene;
DOI:10.1002/anie.200462101
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NEt3 / CH2Cl2
2: 90 percent Spectr. / (S)-2-{[3,5-(CF3)2C6H3]2(TMSO)C}pyrrolidine / toluene / 3 h / 20 °C
3: NaBH4 / toluene; methanol / 0.33 h / 20 °C
4: CH2Cl2
With
(S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; sodium tetrahydroborate; triethylamine;
In
methanol; dichloromethane; toluene;
DOI:10.1002/anie.200462101
