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  • Good Price Dibenzyl Disulfide for Flavor and Fragrance Pharmaceutical Intermediates Pesticide Chemical Dibenzyl disulfide Dibutyl Phosphonate (T-304) E. P. Additive AURORA KA-6695

    Cas No: 150-60-7

  • USD $ 0.35-0.35 / Gram

  • 10 Gram

  • 100 Kilogram/Month

  • Xi'an Faithful Biotech Co., Ltd.
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150-60-7 Usage

Chemical Properties

Benzyl disulfide is a pale yellow leafy or small leafy crystals that has a powerful, burnt-caramel odor; irritating when concentrated. Boiling point >270°C(decomposition). Several insoluble in water, soluble in hot ethanol and ether.


Dibenzyl disulfide has been used in lubricating oil formulations to improve thermal and aging resistance of the oil. It is used an antioxidant in rubber compounding, stabilizer for petroleum fractions, additive to silicone oils. The soly in oils is increased by the presence of benzyl alcohol.


Dibenzyl disulfide is synthesized from benzyl chloride and Na2S2; also from benzyl mercaptan via oxidation.Md. Tajbakhsh et al. (2004) synthesized disulfide from thiols by oxidation with 2,6- DCPCC in acetonitirle at room temperature. For synthesis of DBDS, they used benzyl mercaptan. In 8 min, 96% yield was obtained.Vivek Polshettiwar et al. (2003) obtained disulfide from reaction of alkyl halide with reagent (C6H5CH2N(Et)3)6Mo7S24 in presence of CHCl3 at room temperature. Pure disulfide was obtained by purification by column chromatography method on silica gel. 89% yield was obtained.


Dibenzyl Disulfide (DBDS) is one of several sulfur compounds known to cause copper corrosion in transformers under certain circumstances. Originating from Petiveria alliacea L. This compound along with the other sulfur-containing compound found in this plant display antibacterial and antifungal activity.


ChEBI: Dibenzyl disulfide is an organic disulfide that results from the formal oxidative dimerisation of benzyl thiol. It has a role as a metabolite. It is an organic disulfide and an organic aromatic compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 2998, 1989 DOI: 10.1021/jo00274a002Synthetic Communications, 22, p. 3277, 1992 DOI: 10.1080/00397919208021143Tetrahedron Letters, 31, p. 5007, 1990 DOI: 10.1016/S0040-4039(00)97790-6

General Description

Dibenzyl Disulfide (DBDS) also called Benzyl disulfide is an aromatic disulfide with molecular formula C14H14S2. It has a structural unit, which consists of a linked pair of sulfur atoms. It is insoluble in water whereas soluble in hot methanol, benzene, ether and hot ethanol. Large disulfides-linked agglomerates are rifely found in proteins and many other biologically active molecules.

Purification Methods

Crystallise the disulfide from EtOH (m 77o), pet ether or CS2 (m 72o) or distil it. The AgNO3 complex has m 103o. [Beilstein 6 H 465, 6 I 229, 6 II 437, 6 III 1635, 6 IV 2760.]

Check Digit Verification of cas no

The CAS Registry Mumber 150-60-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 150-60:
37 % 10 = 7
So 150-60-7 is a valid CAS Registry Number.

150-60-7 Well-known Company Product Price

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  • Alfa Aesar

  • (L11850)  Dibenzyl disulfide, 98+%   

  • 150-60-7

  • 25g

  • 150.0CNY

  • Detail
  • Alfa Aesar

  • (L11850)  Dibenzyl disulfide, 98+%   

  • 150-60-7

  • 100g

  • 288.0CNY

  • Detail
  • USP

  • (1062020)  Benzyl disulfide  United States Pharmacopeia (USP) Reference Standard

  • 150-60-7

  • 1062020-200MG

  • 4,647.24CNY

  • Detail
  • Aldrich

  • (B21805)  Dibenzyldisulfide  98%

  • 150-60-7

  • B21805-100G

  • 402.48CNY

  • Detail
  • Aldrich

  • (B21805)  Dibenzyldisulfide  98%

  • 150-60-7

  • B21805-500G

  • 1,590.03CNY

  • Detail

150-60-7Related news

Experimental study of the thermal stability of irgamet 39 and Dibenzyl disulfide (cas 150-60-7) in the laboratory and in transformers in service09/30/2019

In recent years, several documented cases of transformer failures have been attributed to the presence of corrosive sulfur species in the insulating oil [1], [2]. However, all sources of corrosive sulfur in oil have not been completely identified, yet. They can be residuals from the refining pro...detailed

Thermal Reactions of Dibenzyl disulfide (cas 150-60-7) and Dibenzyl Sulfide with Metals: A New Route to trans-Stilbene and Dibenzyl09/29/2019

A procedure was developed for preparing stilbene by thermal desulfuring of dibenzyl disulfide and dibenzyl sulfide with metals (Fe, Zn). The major product of the similar reaction of dibenzyl disulfide with copper is dibenzyl.detailed

Effects of Dibenzyl disulfide (cas 150-60-7) on pressboard09/28/2019

Pressboard is a hard and rigid board having high with excellent electrical and mechanical properties, is specifically produced for the high voltage and extra high voltage Transformer Industry. Components and insulating sheets of pressboard are used in oil-cooled power transformers and distributi...detailed

150-60-7Relevant articles and documents

NaI-Mediated Acetamidosulfenylation of Alkenes with Bunte Salts as Thiolating Reagent Leading to β-Acetamido Sulfides

Zhang, Rongxing,Yan, Zhaohua,Wang, Dingyi,Wang, Yuanxing,Lin, Sen

, p. 1195 - 1200 (2017)

A direct and efficient method for the acetamidosulfenylation reaction of alkenes was developed, in which NaI was used as a catalyst, DMSO as the oxidant, nitriles as both the solvent and nucleophiles and stable, readily available Bunte salts as thiolating reagents. The reactions were carried out under mild conditions generating β-acetamido sulfides in good yields. Moreover, the reaction can be performed when alcohols are used as nucleophiles providing the corresponding β-alkoxysulfides in moderate yields, respectively.

Direct preparation of anhydrous sodium oligosulfides from metal sodium and elemental sulfur in aprotic organic media directed toward synthesis of silane coupling agent

Yamada, Nobuo,Furukawa, Mutsuhisa,Nishi, Masayuki,Takata, Toshikazu

, p. 454 - 455 (2002)

Anhydrous sodium oligosulfide was prepared by the heterogeneous reaction of metal sodium and elemental sulfur in aprotic solvents. The oligosulfide consisted of a mixture of several Na2Sn (n = 2 - 8). Organic oligosulfides (R2Sn, n ≥ 2) including moisture-sensitive one were synthesized by the reaction with organic halides in high yeilds under mild conditions.

Reductive Dimerization of Organic Thiocyanates to Disulfides Mediated by Tetrathiomolybdate

Prabhu, Kandikere R.,Ramesha, A. R.,Chandrasekaran, Srinivasan

, p. 7142 - 7143 (1995)

An interesting reductive dimerization of organic thiocyanates assisted by benzyltriethylammonium tetrathiomolybdate, , 1, leads to the formation of the corresponding disulfides in high yields.

Sulfur transfer reactions of tetrathiomolybdate in water: Synthesis of alkyl disulfides from alkyl halides

Ilankumaran, Palanichamy,Prabhu, Kandikere R.,Chandrasekaran, Srinivasan

, p. 4031 - 4034 (1997)

Reaction of a number of alkyl halides with tetrathiomolybdate in water as the solvent affords the corresponding disulfides in good yields.

The oxidation of mercaptans by flavins.


, p. 3901 - 3904 (1969)




, p. 2270,2271 (1964)


Imidazole Promoted Highly Efficient Large-Scale Thiol-Free Synthesis of Symmetrical Disulfides in Aqueous Media

Mokhtari, Babak,Kiasat, Ali Reza,Monjezi, Javid

, p. 1573 - 1579 (2015)

A highly efficient and environmentally friendly method for the imidazole promoted preparation of symmetrical organic disulfides from Bunte salts is described. This thiol-free procedure produces the desired disulfides even on a large scale by reaction of Bunte salts with imidazole in good to high yields in aqueous media.

Kinetic investigation on liquid-liquid-solid phase transfer catalyzed synthesis of dibenzyl disulfide with H2S-laden monoethanolamine

Singh, Gaurav,Nakade, Priya G.,Mishra, Pratik,Jha, Preeti,Sen, Sujit,Mondal, Ujjal

, p. 78 - 86 (2016)

An investigation has been done on the utilization of H2S for the synthesis of dibenzyl disulfide (DBDS) using Amberlite IR-400 as a phase transfer catalyst. This involves absorption of H2S in aqueous monoethanolamine (MEA) followed by reaction of this H2S-laden MEA with organic reactant benzyl chloride (BC) to yield DBDS under liquid-liquid-solid (L-L-S) phase transfer catalysis condition. The effect of various parameters on the conversion of BC was studied and the selectivity of desired product was 100% at some level of process parameters. A suitable reaction mechanism has been proposed and a mathematical model has been developed to explain the kinetics of the reaction. Waste minimization was therefore affected with the utilization of H2S-laden gas for production of a value-added fine chemical.

Phthalimidomethyl Group. A New Protecting Group of Thiols

Gong, Young-Dae,Iwasawa, Nobuharu

, p. 2139 - 2142 (1994)

Phthalimidomethyl group is employed as a protecting group of thiols.This group can be introduced to thiols under mild reaction conditions and be removed by treatment with hydrazine hydrate followed by mercuric acetate or cupric acetate.



, p. 5549 (1987)


Reactivities of organic isothiocyanates and thiocyanates toward dialkyl bis(phosphine) complexes of palladium(II) and platinum(II)

Lee, Seon Gye,Choi, Keun-Young,Kim, Yong-Joo,Park, Sujin,Lee, Soon W.

, p. 880 - 887 (2015)

Room-temperature reactions of trans-[PdEt2L2] (L = PMe3, PEt3, PMe2Ph) with organic isothiocyanates [R-NCS; R = benzyl; CH(CH3)Ph, R-(-) and S-(+); indanyl, S-(+)] afforded the S,S-coordinated Pd(II) complexes [Pd(S2CN-R)L2] containing a dithiocarbonimidato (S2CN-R) group. Similar reactions involving allyl isothiocyanates produced the cationic η3-allyl Pd complex [Pd(η3-allyl)(PMe3)2]+(NCS)-. When [Pd(S2CN-R)(PMe3)2] was treated with 1 equiv of a chelating phosphine [L-L = depe (1,2-bis(diethylphosphino)ethane) and dmpe (1,2-bis(dimethylphosphino)ethane)], the corresponding complexes [Pd(S2CN-R)(L-L)] were produced. Reactions of trans-[PdEt2L2] (L = PMe3, PMe2Ph) with organic thiocyanates (R-SCN; R = benzyl, Et) resulted in the formation of [Pd(CN)2L2] and an organic disulfide by S-C bond cleavage of R-SCN. However, similar reactions of the dimethyl analogs, trans-[PdMe2L2] (L = PMe3, PEt3), with benzyl thiocyanate afforded different products, [Pd(NCS)2L2] or [PdMe(NCS)L2]. Treating [Pt(styrene)(PMe3)2] with benzyl isothiocyanate gave the S-coordinated dithiocarbonimidato Pt(II) complex, [Pt(S2CN-R)(Me3P)2] (R = benzyl). In contrast, cis-[PtEt2(PMe3)2] reacted with the isothiocyanate to afford the trialkyl Pt(IV) complex [PtEt2(SCN)(CH2Ph)(PMe3)2].

Fluorogenic hydrogen sulfide (H2S) donors based on sulfenyl thiocarbonates enable H2S tracking and quantification

Zhao, Yu,Cerda, Matthew M.,Pluth, Michael D.

, p. 1873 - 1878 (2019)

Hydrogen sulfide (H2S) is an important cellular signaling molecule that exhibits promising protective effects. Although a number of triggerable H2S donors have been developed, spatiotemporal feedback from H2S release in biological systems remains a key challenge in H2S donor development. Herein we report the synthesis, evaluation, and application of caged sulfenyl thiocarbonates as new fluorescent H2S donors. These molecules rely on thiol cleavage of sulfenyl thiocarbonates to release carbonyl sulfide (COS), which is quickly converted to H2S by carbonic anhydrase (CA). This approach is a new strategy in H2S release and does not release electrophilic byproducts common from COS-based H2S releasing motifs. Importantly, the release of COS/H2S is accompanied by the release of a fluorescent reporter, which enables the real-time tracking of H2S by fluorescence spectroscopy or microscopy. Dependent on the choice of fluorophore, either one or two equivalents of H2S can be released, thus allowing for the dynamic range of the fluorescent donors to be tuned. We demonstrate that the fluorescence response correlates directly with quantified H2S release and also demonstrate the live-cell compatibility of these donors. Furthermore, these fluorescent donors exhibit anti-inflammatory effects in RAW 264.7 cells, indicating their potential application as new H2S-releasing therapeutics. Taken together, sulfenyl thiocarbonates provide a new platform for H2S donation and readily enable fluorescent tracking of H2S delivery in complex environments.

Practical and efficient recyclable oxidative system for the preparation of symmetrical disulfides under aerobic conditions

Ling, Ong Chiu,Heidelberg, Thorsten,Ching, Juan Joon,Khaligh, Nader Ghaffari

, p. 281 - 294 (2020/12/13)

An efficient and practical oxidative coupling of thiols to symmetrical disulfides is developed at room temperature under aerobic conditions. The commercially available sodium methoxide solution 30 wt. % in methanol together with the air was used as a retrievable promoter system and green oxidant, respectively, for the preparation of symmetrical disulfides. The desired products were obtained in good to high yields by an economical procedure. No overoxidation of the symmetrical disulfides was observed, and various functional groups were well tolerated in the current protocol. Moreover, the new reagent reduces the generation of hazardous waste due to its high reusability. The reaction proceeded in the absence of light, and it was not inhibited by TEMPO. Also, the low yield of TEMPO-benzyl thiol adduct was detected under these conditions. Based on our experiments, a possible mechanism was proposed in the absence and presence of TEMPO.

Direct synthesis of sulfinic esters via ultrasound accelerated tandem reaction of thiols and alcohols with N-bromosuccinimide

Nguyen, Lan-Anh Thi,Le, Tri-Nghia,Duong, Cong-Thang,Vo, Chi-Tam,Duus, Fritz,Luu, Thi Xuan Thi

, p. 519 - 528 (2021/05/27)

The direct transformation of various thiols and simple alcohols with N-bromosuccinimide into sulfinic esters has been investigated by using different categories of base/acidic catalysts as well as co-solvents under varied reaction conditions. The reaction was found out to afford the sulfinic esters with high yields in the absence of catalysts, especially within the shorter time under the acceleration of ultrasonic irradiation than under the longer-lasting conventional stirring conditions.

Photogeneration of thiyl radicals using metal-halide perovskite for highly efficient synthesis of thioethers

Bai, Rong,Che, Yan,Guo, Chunyi,Guo, Zhifen,Liu, Xin,Xing, Hongzhu

, (2021/11/01)

Recently, the use of metal-halide perovskite (MHP) for photoinduced organics transformation has attracted much attention. We report herein the development of photoinduced thiol-ene reaction using inorganic MHP of CsPbBr3 nanocrystal that is visible light-responsive, easy-to-prepare, and cost-effective. Under blue light-emitting diode (LED), a series of thiol substrates are demonstrated to be highly efficient reaction partners to couple with alkenes tolerated with various functional groups, affording diverse thioethers containing C–S bonds. The CsPbBr3-mediated thiol-ene reaction is characterized by high efficiency, broad substrate applicability, excellent yields, and mild conditions. Mechanism investigation shows that the visible light-excited CsPbBr3 induces the generation of thiyl radicals via hole oxidation to initiate the reaction, followed by redox neutral pathway and/or chain transfer pathway to accomplish thiol–olefin coupling. It is notable that CsPbBr3 exhibits advanced thiol-ene performance than that using MHP analogs and others. The work presents a new exploration of MHP-mediated transformation and shows great potential of MHPs for radical chemistry.

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