L-Tyrosine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-[(4-methoxy phenyl)methoxy]phenyl]propyl]-O-(phenylmethyl)-, methyl ester

Base Information

Chemical Name:L-Tyrosine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-[(4-methoxy phenyl)methoxy]phenyl]propyl]-O-(phenylmethyl)-, methyl ester
CAS No.:849041-83-4
Molecular Formula:C40H48N2O7
Molecular Weight:668.83
Hs Code.:

L-Tyrosine,
N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-[(4-methoxy
phenyl)methoxy]phenyl]propyl]-O-(phenylmethyl)-, methyl ester

Synonyms:

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Chemical Property of L-Tyrosine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-[(4-methoxy phenyl)methoxy]phenyl]propyl]-O-(phenylmethyl)-, methyl ester

Chemical Property:

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Technology Process of L-Tyrosine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-[(4-methoxy phenyl)methoxy]phenyl]propyl]-O-(phenylmethyl)-, methyl ester

There total 7 articles about L-Tyrosine, N-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-[(4-methoxy phenyl)methoxy]phenyl]propyl]-O-(phenylmethyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 57177-83-0
O-benzyltyrosine methyl ester

: 849041-82-3
{1-formyl-2-[4-(4-methoxy-benzyloxy)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester

: 849041-83-4
(S)-3-(4-Benzyloxy-phenyl)-2-{(S)-2-(tert-butoxycarbonyl-methyl-amino)-3-[4-(4-methoxy-benzyloxy)-phenyl]-propylamino}-propionic acid methyl ester

Guidance literature:: With sodium cyanoborohydride; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1055/s-2004-836065

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 849041-83-4
(S)-3-(4-Benzyloxy-phenyl)-2-{(S)-2-(tert-butoxycarbonyl-methyl-amino)-3-[4-(4-methoxy-benzyloxy)-phenyl]-propylamino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / aq. K₂CO₃ / tetrahydrofuran / 0 °C

2: 99 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

3: 90 percent / NaBH₃CN / dimethylformamide / 0 °C

With oxalyl dichloride; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Swern oxidation;
DOI:10.1055/s-2004-836065

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 849041-83-4
(S)-3-(4-Benzyloxy-phenyl)-2-{(S)-2-(tert-butoxycarbonyl-methyl-amino)-3-[4-(4-methoxy-benzyloxy)-phenyl]-propylamino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / K₂CO₃ / dimethylformamide / 20 °C

2: 82 percent / LAH / tetrahydrofuran / Heating

3: 99 percent / aq. K₂CO₃ / tetrahydrofuran / 0 °C

4: 99 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

5: 90 percent / NaBH₃CN / dimethylformamide / 0 °C

With lithium aluminium tetrahydride; oxalyl dichloride; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4: Swern oxidation;
DOI:10.1055/s-2004-836065