1H-Pyrido[3,4-b]indole-2,9-dicarboxylic acid, 3,4-dihydro-1-[4-(phenylmethoxy)butyl]-, 9-(1,1-dimethylethyl) 2-methyl ester

Base Information

Chemical Name:1H-Pyrido[3,4-b]indole-2,9-dicarboxylic acid, 3,4-dihydro-1-[4-(phenylmethoxy)butyl]-, 9-(1,1-dimethylethyl) 2-methyl ester
CAS No.:849092-88-2
Molecular Formula:C29H36N2O5
Molecular Weight:492.615
Hs Code.:

Synonyms:

Suppliers and Price of 1H-Pyrido[3,4-b]indole-2,9-dicarboxylic acid, 3,4-dihydro-1-[4-(phenylmethoxy)butyl]-, 9-(1,1-dimethylethyl) 2-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-Pyrido[3,4-b]indole-2,9-dicarboxylic acid, 3,4-dihydro-1-[4-(phenylmethoxy)butyl]-, 9-(1,1-dimethylethyl) 2-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-Pyrido[3,4-b]indole-2,9-dicarboxylic acid, 3,4-dihydro-1-[4-(phenylmethoxy)butyl]-, 9-(1,1-dimethylethyl) 2-methyl ester

There total 7 articles about 1H-Pyrido[3,4-b]indole-2,9-dicarboxylic acid, 3,4-dihydro-1-[4-(phenylmethoxy)butyl]-, 9-(1,1-dimethylethyl) 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849092-85-9
N-(5-benzyloxy-pent-1-ynyl)-N-[2-(1H-indol-3-yl)-ethyl]-4-methyl-benzenesulfonamide

: 849092-88-2
1-(4-benzyloxy-butyl)-3,4-dihydro-1H-β-carboline-2,9-dicarboxylic acid 9-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / p-nitrobenzenesulfonic acid / toluene / 0.08 h / 70 °C

2: Pd(OH)2 / ethyl acetate; ethanol / 48 h / 20 °C / 4137.18 Torr

3: Na; naphthalene / 1,2-dimethoxy-ethane / -78 - 20 °C

4: Et₃N / tetrahydrofuran / 12 h / 20 °C

5: 232.0 mg / DMAP / CH₂Cl₂ / 4 h / 20 °C

With dmap; naphthalene; p-nitrobenzenesulfonic acid; sodium; triethylamine; palladium dihydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate; toluene; 1: Pictet-Spengler cyclization;
DOI:10.1021/ol0473391

Reference yield:

: 849092-86-0
1-(4-benzyloxy-butylidene)-2-(toluene-4-sulfonyl)-2,3,4,9-tetrahydro-1H-β-carboline

: 849092-88-2
1-(4-benzyloxy-butyl)-3,4-dihydro-1H-β-carboline-2,9-dicarboxylic acid 9-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Pd(OH)2 / ethyl acetate; ethanol / 48 h / 20 °C / 4137.18 Torr

2: Na; naphthalene / 1,2-dimethoxy-ethane / -78 - 20 °C

3: Et₃N / tetrahydrofuran / 12 h / 20 °C

4: 232.0 mg / DMAP / CH₂Cl₂ / 4 h / 20 °C

With dmap; naphthalene; sodium; triethylamine; palladium dihydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/ol0473391

Reference yield:

: 61-54-1
tryptamine

: 849092-88-2
1-(4-benzyloxy-butyl)-3,4-dihydro-1H-β-carboline-2,9-dicarboxylic acid 9-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / Et₃N / tetrahydrofuran

2: 62 percent / K₃PO₄; CuSO₄*5H₂O; 1,10-phenanthroline / DMF / toluene / 32 h / 75 °C

3: 67 percent / p-nitrobenzenesulfonic acid / toluene / 0.08 h / 70 °C

4: Pd(OH)2 / ethyl acetate; ethanol / 48 h / 20 °C / 4137.18 Torr

5: Na; naphthalene / 1,2-dimethoxy-ethane / -78 - 20 °C

6: Et₃N / tetrahydrofuran / 12 h / 20 °C

7: 232.0 mg / DMAP / CH₂Cl₂ / 4 h / 20 °C

With dmap; potassium phosphate; 1,10-Phenanthroline; naphthalene; p-nitrobenzenesulfonic acid; sodium; copper(II) sulfate; triethylamine; palladium dihydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate; toluene; 3: Pictet-Spengler cyclization;
DOI:10.1021/ol0473391