849092-85-9

Upstream product

• 61-54-1 tryptamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 86658-78-8 N-tosyl tryptamine 

Downstream Products

• 849092-95-1 1-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-(toluene-4-sulfonyl)-2,3,4,9-tetrahydro-1H-β-carboline 
• 849092-96-2 1-(4-hydroxy-butyl)-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-β-carboline-9-carboxylic acid tert-butyl ester 
• 849092-88-2 1-(4-benzyloxy-butyl)-3,4-dihydro-1H-β-carboline-2,9-dicarboxylic acid 9-tert-butyl ester 2-methyl ester 
• 849092-87-1 1-(4-benzyloxy-butyl)-2-(toluene-4-sulfonyl)-2,3,4,9-tetrahydro-1H-β-carboline 
• 849093-09-0 1-(4-oxo-butyl)-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-β-carboline-9-carboxylic acid tert-butyl ester 
• 849092-86-0 1-(4-benzyloxy-butylidene)-2-(toluene-4-sulfonyl)-2,3,4,9-tetrahydro-1H-β-carboline 

Relevant academic research and scientific papers

Copper(II)-catalyzed amidations of alkynyl bromides as a general synthesis of ynamides and Z-enamides. An intramolecular amidation for the synthesis of macrocydic ynamides

A general and efficient method for the coupling of a wide range of amides with alkynyl bromides is described here. This novel amidation reaction involves a catalytic protocol using copper(II) sulfate-pentahydrate and 1,10-phenanthroline to direct the sp-C-N bond formation, leading to a structurally diverse array of ynamides including macrocyclic ynamides via an intramolecular amidation. Given the surging interest in ynamide chemistry, this atom economical synthesis of ynamides should invoke further attention from the synthetic organic community.

Bronsted acid-catalyzed highly stereoselective arene-ynamide cyclizations. A novel keteniminium Pictet-Spengler cyclization in total syntheses of (±)-desbromoarborescidines A and C

(Chemical Equation Presented) A Bronsted acid-catalyzed highly stereoselective arene-ynamide cyclization is described. These reactions constitute a keteniminium variant of Pictet-Spengler cyclizations, leading to efficient synthesis of nitrogen heterocycl