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4'-Chloro-5-fluoro-2-hydroxybenzophenone

Base Information Edit
  • Chemical Name:4'-Chloro-5-fluoro-2-hydroxybenzophenone
  • CAS No.:62433-26-5
  • Molecular Formula:C13H8 Cl F O2
  • Molecular Weight:250.657
  • Hs Code.:2914700090
  • European Community (EC) Number:263-539-2
  • DSSTox Substance ID:DTXSID40211476
  • Nikkaji Number:J227.882K
  • Wikidata:Q72450786
  • Mol file:62433-26-5.mol
4'-Chloro-5-fluoro-2-hydroxybenzophenone

Synonyms:62433-26-5;(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methanone;4'-Chloro-5-fluoro-2-hydroxybenzophenone;(4-chlorophenyl)-(5-fluoro-2-hydroxyphenyl)methanone;EINECS 263-539-2;Methanone, (4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)-;4-Chloro-5'-fluoro-2'-hydroxybenzophenone;2-(4-chlorobenzoyl)-4-fluorophenol;SCHEMBL143515;EthylN-Cbz-2-piperidineacetate;DTXSID40211476;MFCD00040948;AKOS015913537;DS-4656;2-hydroxy-5-fluoro-4'-chloro-benzophenone;4'-chloro-5-fluoro-2-hydroxy-benzophenone;4/'-Chloro-5-fluoro-2-hydroxybenzophenone;SL-79-182;C3338;CS-0157560;FT-0618114;4'-Chloro-5-fluoro-2-hydroxybenzophenone, 96%;A833767

Suppliers and Price of 4'-Chloro-5-fluoro-2-hydroxybenzophenone
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • 4''-Chloro-5-fluoro-2-hydroxybenzophenone
  • 50mg
  • $ 85.00
  • TRC
  • 4''-Chloro-5-fluoro-2-hydroxybenzophenone
  • 5g
  • $ 635.00
  • TRC
  • 4''-Chloro-5-fluoro-2-hydroxybenzophenone
  • 2.5g
  • $ 360.00
  • TCI Chemical
  • 4'-Chloro-5-fluoro-2-hydroxybenzophenone >97.0%(GC)
  • 5g
  • $ 428.00
  • TCI Chemical
  • 4'-Chloro-5-fluoro-2-hydroxybenzophenone >97.0%(GC)
  • 1g
  • $ 143.00
  • SynQuest Laboratories
  • 4'-Chloro-5-fluoro-2-hydroxybenzophenone 97%
  • 1 g
  • $ 154.00
  • Heterocyclics
  • (4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methanone 96%
  • 250mg
  • $ 79.00
  • Heterocyclics
  • (4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methanone 96%
  • 1g
  • $ 95.00
  • Heterocyclics
  • (4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methanone 96%
  • 5g
  • $ 319.00
  • Crysdot
  • (4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methanone 95+%
  • 5g
  • $ 392.00
Total 18 raw suppliers
Chemical Property of 4'-Chloro-5-fluoro-2-hydroxybenzophenone Edit
Chemical Property:
  • Melting Point:65-69 °C(lit.)
     
  • Boiling Point:145-152/5mm 
  • Flash Point:177.2ºC 
  • PSA:37.30000 
  • Density:1.376g/cm3 
  • LogP:3.41570 
  • Storage Temp.:2-8°C 
  • Water Solubility.:8.999mg/L(37 oC) 
  • XLogP3:4
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:2
  • Exact Mass:250.0196853
  • Heavy Atom Count:17
  • Complexity:277
Purity/Quality:

97% *data from raw suppliers

4''-Chloro-5-fluoro-2-hydroxybenzophenone *data from reagent suppliers

Safty Information:
  • Pictogram(s): Xi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26-36 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1=CC(=CC=C1C(=O)C2=C(C=CC(=C2)F)O)Cl
  • Uses 4''-Chloro-5-fluoro-2-hydroxybenzophenone is a metabolite of Progabide (P755350) which is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity. 4''-Chloro-5-fluoro-2-hydroxybenzophenone is also used as a reagent in the synthesis of a series of novel dihydrobenzofuranols which displayed antibacterial activity comparable to bacitracin, ciprofloxacin and gentamicin.
Technology Process of 4'-Chloro-5-fluoro-2-hydroxybenzophenone

There total 8 articles about 4'-Chloro-5-fluoro-2-hydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
O-4-fluorophenyl N,N-diethylcarbamate; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 - -65 ℃; for 1.58333h; Inert atmosphere;
4-Cyanochlorobenzene; In tetrahydrofuran; cyclohexane; at -65 - 20 ℃; Inert atmosphere;
With hydrogenchloride; In tetrahydrofuran; cyclohexane; water; Inert atmosphere;
DOI:10.1021/acs.orglett.8b00782
Guidance literature:
With hydrogenchloride; In water; for 16h; Inert atmosphere;
DOI:10.1021/acs.joc.0c01732
Guidance literature:
With aluminium trichloride; at 200 ℃; for 0.25h;
DOI:10.1021/jm00180a029
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