2,4,9-trihydroxy-6-methoxy-7-methyl-2-(2-oxopropyl)-1H-phenalene-1,3(2H)-dione

Base Information

• Chemical Name: 2,4,9-trihydroxy-6-methoxy-7-methyl-2-(2-oxopropyl)-1H-phenalene-1,3(2H)-dione
• CAS No.: 124190-19-8
• Molecular Formula: C₁₈H₁₆O₇
• Molecular Weight: 344.321
• Mol file: 124190-19-8.mol

Synonyms:FR 901235

Chemical Property of 2,4,9-trihydroxy-6-methoxy-7-methyl-2-(2-oxopropyl)-1H-phenalene-1,3(2H)-dione

Chemical Property:

• Vapor Pressure: 1.6E-19mmHg at 25°C
• Boiling Point: 681.8°Cat760mmHg
• Flash Point: 252.6°C
• Density: 1.501g/cm³

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,9-trihydroxy-6-methoxy-7-methyl-2-(2-oxopropyl)-1H-phenalene-1,3(2H)-dione

There total 5 articles about 2,4,9-trihydroxy-6-methoxy-7-methyl-2-(2-oxopropyl)-1H-phenalene-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

C15H12O5 + acetone (67-64-1) → FR-901235 (124190-19-8)

Guidance literature:

With peracetic acid; acetic acid; In ethyl acetate; at 60 ℃;

DOI:10.1021/acs.orglett.0c03401

Reference yield:

C23H18O6 → FR-901235 (124190-19-8)

Guidance literature:

Multi-step reaction with 5 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 4.5 h / 20 °C

2: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5.5 h / 40 °C

3: water; sodium hydroxide / ethanol; tetrahydrofuran / 20 °C

4: sulfuric acid / dichloromethane; methanol / 48 h / 40 °C

5: acetic acid; peracetic acid / ethyl acetate / 60 °C

With peracetic acid; sulfuric acid; water; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 2: |Baeyer-Villiger Ketone Oxidation;

DOI:10.1021/acs.orglett.0c03401

Reference yield:

C25H22O7 → FR-901235 (124190-19-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5.5 h / 40 °C

2: water; sodium hydroxide / ethanol; tetrahydrofuran / 20 °C

3: sulfuric acid / dichloromethane; methanol / 48 h / 40 °C

4: acetic acid; peracetic acid / ethyl acetate / 60 °C

With peracetic acid; sulfuric acid; water; sodium hydrogencarbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; 1: |Baeyer-Villiger Ketone Oxidation;

DOI:10.1021/acs.orglett.0c03401

upstream raw materials:

acetone