Azarole

Base Information

• Chemical Name: Azarole
• CAS No.: 55872-82-7
• Molecular Formula: C₁₄H₁₂N₄
• Molecular Weight: 236.276
• Mol file: 55872-82-7.mol

Synonyms:Azarole;Azarole (pharmaceutical)

Chemical Property of Azarole

Chemical Property:

• Boiling Point: 461.7°Cat760mmHg
• Flash Point: 233°C
• PSA: 34.58000
• Density: 1.16g/cm³
• LogP: 2.52400

Purity/Quality:

AZAROLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Immunoregulator.

Technology Process of Azarole

There total 2 articles about Azarole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

1H-pyrrol-1-amine (765-39-9) + p-benzoquinone (106-51-4) → syn-N,N'-(2,5-cyclohexadiene-1,4-diylidene)bis-1H-pyrrol-1-amine (55872-82-7,79381-19-4,79381-25-2) + anti-N,N'-(2,5-cyclohexadiene-1,4-diylidene)bis-1H-pyrrol-1-amine (55872-82-7,79381-19-4,79381-25-2)

Guidance literature:

With trifluoroacetic acid; In diethyl ether; Ambient temperature;

DOI:10.1021/jm00143a011

Reference yield: 42.0%

1H-pyrrol-1-amine (765-39-9) + p-benzoquinone (106-51-4) → syn-N,N'-(2,5-cyclohexadiene-1,4-diylidene)bis-1H-pyrrol-1-amine (55872-82-7,79381-19-4,79381-25-2) + anti-N,N'-(2,5-cyclohexadiene-1,4-diylidene)bis-1H-pyrrol-1-amine (55872-82-7,79381-19-4,79381-25-2)

Guidance literature:

With trifluoroacetic acid; In diethyl ether; Ambient temperature;

DOI:10.1021/jm00143a011

Reference yield: 95.0%

anti-N,N'-(2,5-cyclohexadiene-1,4-diylidene)bis-1H-pyrrol-1-amine (55872-82-7,79381-19-4,79381-25-2) → 1,1'-[(1,4-phenylene)diamino]dipyrrole (55872-83-8)

Guidance literature:

With sodium dithionite; In water; N,N-dimethyl-formamide; for 1h;

DOI:10.1021/jm00143a011

upstream raw materials:

1H-pyrrol-1-amine

p-benzoquinone

Downstream raw materials:

1,1'-[(1,4-phenylene)diamino]dipyrrole