5-AMino-6-broMopicolinonitrile

Base Information

• Chemical Name: 5-AMino-6-broMopicolinonitrile
• CAS No.: 849353-22-6
• Molecular Formula: C6H4BrN3
• Molecular Weight: 198.02000
• Hs Code.: 2933399090
• Mol file: 849353-22-6.mol

Synonyms:aminobromopyridinecarbonitrile;5-Amino-6-bromo-2-pyridinecarbonitrile;5-Amino-6-bromopicolinonitrile;

Chemical Property of 5-AMino-6-broMopicolinonitrile

Chemical Property:

• Boiling Point: 375.7±42.0 °C(Predicted)
• PKA: -2.36±0.10(Predicted)
• PSA: 62.70000
• Density: 1.80±0.1 g/cm3(Predicted)
• LogP: 1.87918
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-6-bromopyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMino-6-broMopicolinonitrile

There total 1 articles about 5-AMino-6-broMopicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

5-amino-2-cyanopyridine (55338-73-3) → 5-amino-6-bromopyridine-2-carbonitrile (849353-22-6)

Guidance literature:

With bromine; In acetic acid; at 20 ℃; for 1.5h;

Reference yield: 95.0%

5-amino-6-bromopyridine-2-carbonitrile (849353-22-6) + 4-fluoroboronic acid (1765-93-1) → 5-amino-6-(4-fluorophenyl)pyridine-2-carbonitrile

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; toluene; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b01240

Reference yield:

5-amino-6-bromopyridine-2-carbonitrile (849353-22-6) → 8-[4-(4-methylpiperazin-1-yl)phenyl]-5H-dipyrido[2,3-b:2',3'-d]pyrrole-2-carbonitrile

Guidance literature:

Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; acetonitrile / Microwave irradiation

2: sodium hexamethyldisilazane / tetrahydrofuran / 50 °C

3: bromine; sodium acetate; acetic acid / 80 °C / Sealed tube

4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; acetonitrile / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; bromine; sodium acetate; sodium hexamethyldisilazane; sodium carbonate; acetic acid; In tetrahydrofuran; water; acetonitrile; 1: |Suzuki-Miyaura Coupling / 4: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.bmcl.2014.10.063

upstream raw materials:

5-amino-2-cyanopyridine

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