55338-73-3

Basic information

• Product Name: 3-Amino-6-cyanopyridine
• Synonyms: 3-AMINO-6-CYANOPYRIDINE;5-AMINO-2-CYANOPYRIDINE;5-AMINO-PYRIDINE-2-CARBONITRILE;5-Aminopicolinonitrile;2-Cyano-5-Aminopyridine;5-Amino-2-pyridinecarbonitrile, 96%;5-Amino-2-pyridine nitrile;2-carbonitrile-5-aminopyridine
• CAS NO: 55338-73-3
• Molecular Formula: C₆H₅N₃
• Molecular Weight: 119.12
• Product Categories: Pyridine;Building Blocks;C6;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines;Heterocycle-Pyridine series
• Mol File: 55338-73-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 148-152 °C(lit.)
• Boiling Point: 368.2 °C at 760 mmHg
• Flash Point: 176.5 °C
• Appearance: brown powder
• Density: 1.23 g/cm³
• Vapor Pressure: 1.29E-05mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.61±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-6-cyanopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-6-cyanopyridine(55338-73-3)
• EPA Substance Registry System: 3-Amino-6-cyanopyridine(55338-73-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• RIDADR: 3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 55338-73-3(Hazardous Substances Data)

Usage

Chemical Properties

Brown powder

Uses

5-Amino-2-pyridinecarbonitrile (5-Amino-2-cyanopyridine) may be used to synthesize 5-amino-2-pyridine.

InChI:InChI=1/C6H5N3/c7-3-6-2-1-5(8)4-9-6/h1-2,4H,8H2

Upstream product

• 100367-55-3 5-nitropyridine-2-carbonitrile 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 4487-59-6 2-bromo-5-nitropyridine 

Downstream Products

• 24242-20-4 5-amino-pyridine-2-carboxylic acid 
• 1159997-24-6 (R)-N-(6-cyanopyridin-3-yl)-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroiso-quinoline-2(1H)-carboxamide 
• 1441873-63-7 N-benzyl-6-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyridin-3-amine 
• 1429510-82-6 5-amino-4,6-dimethylpicolinonitrile 
• 1430844-69-1 N-(6-cyanopyridin-3-yl)-N-methyl-2-nitrobenzenesulfonamide 
• 1430844-68-0 N-(6-cyanopyridin-3-yl)-2-nitrobenzenesulfonamide 
• 1419604-29-7 phenyl 6-((2-methoxyethyl-N-tert-butoxycarbonyl-amino)methyl)pyridin-3-ylcarbamate 
• 1419597-61-7 5-(3-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)ureido)picolinamide 
• 1419602-67-7 1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-cyanopyridin-3-yl)urea 
• 1419604-19-5 5-(dibenzylamino)picolinonitrile 
• 1419601-02-7 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(((2-hydroxyethyl)(methyl)amino)methyl)pyridin-3-yl)urea 
• 1419604-37-7 phenyl 6-(((2-hydroxyethyl)(methyl)amino)methyl)pyridin-3-ylcarbamate 
• 1419604-33-3 2-(((5-(dibenzylamino)pyridin-2-yl)methyl)(methyl)amino)ethanol 
• 1419600-99-9 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-((2-hydroxyethylamino)methyl)pyridin-3-yl)urea 

Relevant articles and documents

Preparation method of 2-nitrile-5-hydroxypyridine

The invention relates to a preparation method of 2-nitrile-5-hydroxypyridine. The method comprises the steps: taking 2-bromine-5-nitropyridine, NaCN, CuCN, dimethylformamide, KH2PO4 and the like as starting raw materials to generate 2-nitrile-5-nitropyridine, adding ethyl acetate, an appropriate amount of reduced Fe powder and an enough amount of acetic acid, adding an appropriate amount of H2SO4 solution and NaNO2, and performing filtering and drying to obtain orange-yellow solid 2-nitrile-5-hydroxypyridine. The method is mild in reaction condition and low in cost; the raw materials are easy to obtain; and the method is suitable for mass production of a plant.

NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION

The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, W and X are as described herein, compositions including the compounds and methods of using the compounds.

The Synthesis of the High-Potency Sweetener, NC-00637. Part 2: Preparation of the Pyridine Moiety

The pyridine moiety within the high-potency sweetener, NC-00637 (1), 5-amino-2-cyanopyridine (4), was prepared from 2-hydroxy-5-nitropyridine (10). The sequence involved the conversion of the hydroxy group to bromide followed by substitution with cyanide to give 2-cyano-5-nitropyridine (8). Reduction of the nitro group proved to be troublesome when catalytic hydrogenation was used. Iron with an acid gave a reproducible reaction that could be used at scale.