Methanesulfonic acid, trifluoro-, 3-[2,5-dihydro-1-methyl-2,5-dioxo-4-[5-(phenylmethoxy)-1-(phenylsulfon yl)-1H-indol-3-yl]-1H-pyrrol-3-yl]-2-naphthalenyl ester

Base Information

Chemical Name:Methanesulfonic acid, trifluoro-, 3-[2,5-dihydro-1-methyl-2,5-dioxo-4-[5-(phenylmethoxy)-1-(phenylsulfon yl)-1H-indol-3-yl]-1H-pyrrol-3-yl]-2-naphthalenyl ester
CAS No.:849404-41-7
Molecular Formula:C37H25F3N2O8S2
Molecular Weight:746.741
Hs Code.:

Methanesulfonic acid, trifluoro-,
3-[2,5-dihydro-1-methyl-2,5-dioxo-4-[5-(phenylmethoxy)-1-(phenylsulfon
yl)-1H-indol-3-yl]-1H-pyrrol-3-yl]-2-naphthalenyl ester

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Chemical Property of Methanesulfonic acid, trifluoro-, 3-[2,5-dihydro-1-methyl-2,5-dioxo-4-[5-(phenylmethoxy)-1-(phenylsulfon yl)-1H-indol-3-yl]-1H-pyrrol-3-yl]-2-naphthalenyl ester

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Technology Process of Methanesulfonic acid, trifluoro-, 3-[2,5-dihydro-1-methyl-2,5-dioxo-4-[5-(phenylmethoxy)-1-(phenylsulfon yl)-1H-indol-3-yl]-1H-pyrrol-3-yl]-2-naphthalenyl ester

There total 8 articles about Methanesulfonic acid, trifluoro-, 3-[2,5-dihydro-1-methyl-2,5-dioxo-4-[5-(phenylmethoxy)-1-(phenylsulfon yl)-1H-indol-3-yl]-1H-pyrrol-3-yl]-2-naphthalenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 849404-38-2
3-(1-benzenesulfonyl-5-benzyloxy-1H-indol-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione

: 849404-41-7
trifluoromethanesulfonic acid 3-[4-(1-benzenesulfonyl-5-benzyloxy-1H-indol-3-yl)-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]naphthalen-2-yl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1021/jm049213f

Reference yield:

: 93-04-9
2-Methoxynaphthalene

: 849404-41-7
trifluoromethanesulfonic acid 3-[4-(1-benzenesulfonyl-5-benzyloxy-1H-indol-3-yl)-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]naphthalen-2-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -10 - 0 °C

1.2: hexane; tetrahydrofuran / 1 h / 20 °C

2.1: 1.99 g / aq. HCl / hexane; tetrahydrofuran

3.1: 85 percent / BBr₃ / CH₂Cl₂ / 2 h / 20 °C

4.1: 82 percent / Pd(OAc)2; aq. K₂CO₃ / dioxane / 2 h / 100 °C

5.1: 88 percent / NEt₃ / CH₂Cl₂ / 3 h / 0 - 20 °C

With hydrogenchloride; palladium diacetate; n-butyllithium; boron tribromide; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; 4.1: Suzuki coupling reaction;
DOI:10.1021/jm049213f

Reference yield:

: 104115-76-6
3-methoxynaphthalen-2-ylboronic acid

: 849404-41-7
trifluoromethanesulfonic acid 3-[4-(1-benzenesulfonyl-5-benzyloxy-1H-indol-3-yl)-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]naphthalen-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / BBr₃ / CH₂Cl₂ / 2 h / 20 °C

2: 82 percent / Pd(OAc)2; aq. K₂CO₃ / dioxane / 2 h / 100 °C

3: 88 percent / NEt₃ / CH₂Cl₂ / 3 h / 0 - 20 °C

With palladium diacetate; boron tribromide; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; 2: Suzuki coupling reaction;
DOI:10.1021/jm049213f