Deferoxamine mesylate

Base Information Edit

Chemical Name:Deferoxamine mesylate
CAS No.:138-14-7
Deprecated CAS:17688-38-9,35908-62-4
Molecular Formula:C25H48N6O8^.CH4O3S
Molecular Weight:656.798
Hs Code.:29280000
European Community (EC) Number:205-314-3
NSC Number:756718,644468
UNII:V9TKO7EO6K
DSSTox Substance ID:DTXSID6037649
Wikidata:Q27114315
NCI Thesaurus Code:C417
RXCUI:3132
ChEMBL ID:CHEMBL1234
Mol file:138-14-7.mol

Synonyms:Deferoxamine;Deferoxamine B;Deferoxamine Mesilate;Deferoxamine Mesylate;Deferoxamine Methanesulfonate;Deferoximine;Deferrioxamine B;Desferal;Desferioximine;Desferrioxamine;Desferrioxamine B;Desferrioxamine B Mesylate;Desferroxamine;Mesilate, Deferoxamine;Mesylate, Deferoxamine;Mesylate, Desferrioxamine B;Methanesulfonate, Deferoxamine

Suppliers and Price of Deferoxamine mesylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Deferoxamine mesylate
250mg
$ 85.00

Tocris
Deferoxamine mesylate
50
$ 63.00

Sigma-Aldrich
Deferoxamine mesylate salt European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Deferoxamine mesylate salt European Pharmacopoeia (EP) Reference Standard
d0160000
$ 190.00

Sigma-Aldrich
Deferoxamine mesylate United States Pharmacopeia (USP) Reference Standard
300mg
$ 366.00

Sigma-Aldrich
Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem
1gm
$ 149.00

Sigma-Aldrich
Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem Parenteralironchelatingagent.Commonlyusedintherapyasachelatorofferri
1 g
$ 148.00

Sigma-Aldrich
Deferoxamine mesylate salt powder, ≥92.5% (TLC)
1g
$ 113.00

Crysdot
Deferoxamine mesylate 98+%
100mg
$ 40.00

ChemScene
Deferoxamine mesylate 99.86%
500mg
$ 96.00

Total 106 raw suppliers

Chemical Property of Deferoxamine mesylate Edit

Chemical Property:

Appearance/Colour:white to off-white powder
Vapor Pressure:0mmHg at 25°C
Melting Point:148-149°
Boiling Point:966.9 °C at 760 mmHg
Flash Point:538.5 °C
PSA：268.59000
LogP:2.98900
Storage Temp.:−20°C
Solubility.:H2O: 50 mg/mL
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:23
Exact Mass:656.34147767
Heavy Atom Count:44
Complexity:832

Purity/Quality:

98% ^*data from raw suppliers

Deferoxamine mesylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O.CS(=O)(=O)O
Recent ClinicalTrials:Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes
Recent EU Clinical Trials:A Phase I/IIa study to evaluate safety, biodistribution, dosimetry and preliminary diagnostic performance of [68Ga]Ga-Deferoxamine for PET imaging in patients with bacterial infections
Description Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 μM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.
Uses DEFEROXAMINE MESYLATE is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients chelating agent (Fe & Al)
Clinical Use Chelating agent:Acute iron poisoningChronic iron or aluminium overload
Drug interactions Potentially hazardous interactions with other drugsAvoid prochlorperazine, levomepromazine and methotrimeprazine (prolonged unconsciousness).Do not administer with blood.

Technology Process of Deferoxamine mesylate

There total 1 articles about Deferoxamine mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: