Octanoic acid, 8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-3,7-dimethyl-2-(phenyl methoxy)-, ethyl ester, (2S,3S)-

Base Information

Chemical Name:Octanoic acid, 8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-3,7-dimethyl-2-(phenyl methoxy)-, ethyl ester, (2S,3S)-
CAS No.:849411-90-1
Molecular Formula:C35H48O5Si
Molecular Weight:576.849
Hs Code.:

Synonyms:

Suppliers and Price of Octanoic acid, 8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-3,7-dimethyl-2-(phenyl methoxy)-, ethyl ester, (2S,3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Octanoic acid, 8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-3,7-dimethyl-2-(phenyl methoxy)-, ethyl ester, (2S,3S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Octanoic acid, 8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-3,7-dimethyl-2-(phenyl methoxy)-, ethyl ester, (2S,3S)-

There total 4 articles about Octanoic acid, 8-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-hydroxy-3,7-dimethyl-2-(phenyl methoxy)-, ethyl ester, (2S,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 100-39-0
benzyl bromide

: 724422-93-9
(2S,3S)-ethyl 8-(tert-butyldiphenylsilanyloxy)-2,3-dihydroxy-3,7-dimethyloctanoate

: 849411-90-1
ethyl (2S,3S)-2-benzyloxy-8-(tert-butyldiphenylsilanyloxy)-3-hydroxy-3,7-dimethyloctanoate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; silver(l) oxide; In dichloromethane; at 20 ℃;
DOI:10.1021/ol049433n

Reference yield:

: 1575-74-2
(+-)-2-methyl-pent-4-enoic acid

: 849411-90-1
ethyl (2S,3S)-2-benzyloxy-8-(tert-butyldiphenylsilanyloxy)-3-hydroxy-3,7-dimethyloctanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: LiAlH₄ / tetrahydrofuran / 16 h / 20 °C

2.1: 91 percent / imidazole / dimethylformamide / 12 h / 20 °C

3.1: 9-BBN dimer / tetrahydrofuran / 2 h / 0 °C

3.2: 74 percent / K₃PO₄ / Pd(PPh₃)4 / tetrahydrofuran; dioxane / 5 h / 85 °C

4.1: AD-mix-β; MeSO2NH2 / H2O; 2-methyl-propan-2-ol; toluene / 30 h / 0 °C

5.1: 74 percent / n-Bu₄NI; Ag₂O / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; methanesulfonamide; AD-mix-β; tetra-(n-butyl)ammonium iodide; silver(l) oxide; dimeric 9-borabicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 3.2: Suzuki-Miyaura coupling / 4.1: Sharpless dihydroxylation;
DOI:10.1021/jo048115z

Reference yield:

: 9-[5-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentyl]-9-bora-bicyclo[3.3.1]nonane

: 849411-90-1
ethyl (2S,3S)-2-benzyloxy-8-(tert-butyldiphenylsilanyloxy)-3-hydroxy-3,7-dimethyloctanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.40 g / K₃PO₄; Pd(PPh₃)4 / dioxane; tetrahydrofuran / 5 h / 85 °C

2: AD-mix β; H2NSO2Me / 2-methyl-propan-2-ol; H2O; toluene / 30 h / 0 °C

3: 74 percent / Ag₂O; n-Bu₄NI / CH₂Cl₂ / 20 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonamide; tetra-(n-butyl)ammonium iodide; 1,4-bis(9-O-dihydroquinidine)phthalazine; silver(l) oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; tert-butyl alcohol; 1: Suzuki cross-coupling reaction / 2: Sharpless dihydroxylation;
DOI:10.1021/ol049433n