Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-propenyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester

Base Information

Chemical Name:Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-propenyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester
CAS No.:849418-92-4
Molecular Formula:C36H55O7PSi
Molecular Weight:658.888
Hs Code.:

Phosphonic acid,
[(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S,
5S,6R)-2,2,5-trimethyl-6-(2-propenyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl
ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-propenyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-propenyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester

There total 2 articles about Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-propenyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 849418-91-3
dimethyl (3R,5R,6S,7S,8R)-5-(2-hydroxyethyl)-6,8-isopropylidenedioxy-3,7-dimethyl-2-oxo-10-undecenylphosphonate

: 849418-92-4
dimethyl (3R,5R,6S,7S,8R)-5-{2-(tert-butyldiphenylsilyloxy)ethyl}-6,8-isopropylidenedioxy-3,7-dimethyl-2-oxo-10-undecenylphosphonate

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.3987/COM-04-S(P)30

Reference yield:

: 113918-79-9
dimethyl (3R,5R,6S,7S,8R)-5-<2-(3,4-dimethoxybenzyloxy)ethyl>-3,7-dimethyl-6,8-isopropylidenedioxy-2-oxo-10-undecenylphosphonate

: 849418-92-4
dimethyl (3R,5R,6S,7S,8R)-5-{2-(tert-butyldiphenylsilyloxy)ethyl}-6,8-isopropylidenedioxy-3,7-dimethyl-2-oxo-10-undecenylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / DDQ / CH₂Cl₂; H₂O / 1 h

2: 90 percent / imidazole / CH₂Cl₂ / 0.5 h / 20 °C

With 1H-imidazole; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water;
DOI:10.3987/COM-04-S(P)30

Reference yield:

: 849418-92-4
dimethyl (3R,5R,6S,7S,8R)-5-{2-(tert-butyldiphenylsilyloxy)ethyl}-6,8-isopropylidenedioxy-3,7-dimethyl-2-oxo-10-undecenylphosphonate

: 849419-01-8
(4R,5S,6S,7R,9R,16S)-7-{2-(tert-butyldiphenylsilyloxy)ethyl}-4,6-isopropylidenedioxy-5,9-dimethyl-{1-methyl-2-{2-methyl-(1,3-thiazol-4-yl)}-1(E)-ethenyl}-11(E),13(E)-diene-2,10-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: NMO; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 21 h / 20 °C

1.2: 83 percent / NaIO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 0.5 h / 20 °C

2.1: 100 percent / 2-methyl-2-butene; NaH₂PO₄; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 0.17 h / 20 °C

3.1: Et₃N; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 1 h / 20 °C

3.2: 76 percent / DMAP / toluene / 23 h / 20 °C

4.1: 46 percent / K₂CO₃; 18-crown-6 / toluene / 22.5 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; osmium(VIII) oxide; N-methyl-2-indolinone; 2-methyl-but-2-ene; 18-crown-6 ether; 2,4,6-trichlorobenzoyl chloride; potassium carbonate; triethylamine; In tetrahydrofuran; water; acetone; toluene; tert-butyl alcohol; 4.1: Horner-Emmons reaction;
DOI:10.3987/COM-04-S(P)30