Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester

Base Information

Chemical Name:Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester
CAS No.:849418-93-5
Molecular Formula:C35H53O8PSi
Molecular Weight:660.86
Hs Code.:

Phosphonic acid,
[(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S,
5S,6R)-2,2,5-trimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl
ester

Synonyms:

Suppliers and Price of Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester

There total 2 articles about Phosphonic acid, [(3R,5R)-7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-2-oxo-5-[(4S, 5S,6R)-2,2,5-trimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]heptyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113918-79-9
dimethyl (3R,5R,6S,7S,8R)-5-<2-(3,4-dimethoxybenzyloxy)ethyl>-3,7-dimethyl-6,8-isopropylidenedioxy-2-oxo-10-undecenylphosphonate

: 849418-93-5
(3R,4S,5S,6R,8R)-10-dimethoxyphosphono-6-{2-(tert-butyldiphenylsilyloxy)ethyl}-3,5-isopropylidenedioxy-3,8-dimethyl-9-oxodecanal

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / DDQ / CH₂Cl₂; H₂O / 1 h

2.1: 90 percent / imidazole / CH₂Cl₂ / 0.5 h / 20 °C

3.1: NMO; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 21 h / 20 °C

3.2: 83 percent / NaIO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 0.5 h / 20 °C

With 1H-imidazole; osmium(VIII) oxide; N-methyl-2-indolinone; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.3987/COM-04-S(P)30

Reference yield:

: 849418-91-3
dimethyl (3R,5R,6S,7S,8R)-5-(2-hydroxyethyl)-6,8-isopropylidenedioxy-3,7-dimethyl-2-oxo-10-undecenylphosphonate

: 849418-93-5
(3R,4S,5S,6R,8R)-10-dimethoxyphosphono-6-{2-(tert-butyldiphenylsilyloxy)ethyl}-3,5-isopropylidenedioxy-3,8-dimethyl-9-oxodecanal

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / imidazole / CH₂Cl₂ / 0.5 h / 20 °C

2.1: NMO; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 21 h / 20 °C

2.2: 83 percent / NaIO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 0.5 h / 20 °C

With 1H-imidazole; osmium(VIII) oxide; N-methyl-2-indolinone; In dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.3987/COM-04-S(P)30

Reference yield: 100.0%

: 849418-93-5
(3R,4S,5S,6R,8R)-10-dimethoxyphosphono-6-{2-(tert-butyldiphenylsilyloxy)ethyl}-3,5-isopropylidenedioxy-3,8-dimethyl-9-oxodecanal

: 849418-89-9
(3R,4S,5S,6R,8R)-10-dimethoxyphosphono-6-{2-(tert-butyldiphenylsilyloxy)ethyl}-3,5-isopropylidenedioxy-3,8-dimethyl-9-oxodecanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 0.166667h;
DOI:10.3987/COM-04-S(P)30