sodium (S)-2-hydroxy-4-methylvalerate

Base Information

• Chemical Name: sodium (S)-2-hydroxy-4-methylvalerate
• CAS No.: 54641-21-3
• Molecular Formula: C6H12 O3 . Na
• Molecular Weight: 154.141
• Hs Code.: 2918199090
• Mol file: 54641-21-3.mol

Synonyms:Pentanoicacid, 2-hydroxy-4-methyl-, monosodium salt, (S)- (9CI)

Chemical Property of sodium (S)-2-hydroxy-4-methylvalerate

Chemical Property:

• Vapor Pressure: 0.00324mmHg at 25°C
• Boiling Point: 251.3°C at 760 mmHg
• Flash Point: 120.1°C
• PSA: 60.36000
• LogP: -0.85670

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of sodium (S)-2-hydroxy-4-methylvalerate

There total 1 articles about sodium (S)-2-hydroxy-4-methylvalerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → (S)-(-)-sodium 2-hydroxy-4-methylpentanoate (54641-21-3)

Guidance literature:

With sodium hydroxide; sulfuric acid; sodium nitrite; Yield given. Multistep reaction; 1.) water, -2-0 deg C, 3 h, overnight, room temp., 2.) water, pH=4.5-5.0;

Reference yield: 82.0%

benzyl bromide (100-39-0) + (S)-(-)-sodium 2-hydroxy-4-methylpentanoate (54641-21-3) → benzyl (2S)-2-hydroxy-4-methylpentanoate (37755-48-9,40298-04-2)

Guidance literature:

In N,N-dimethyl-formamide; for 24h; Ambient temperature;

Reference yield:

(S)-(-)-sodium 2-hydroxy-4-methylpentanoate (54641-21-3) → (S)-1-(benzyloxycarbonyl)-3-methylbuthyl 4'-octocxybiphenyl-4-carboxylate (125150-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / dimethylformamide / 24 h / Ambient temperature

2: 78 percent / DCC, 4-(N-pyrrolidino)pyridine / CH₂Cl₂ / 6 h / Ambient temperature

With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

L-leucine

Downstream raw materials:

benzyl (2S)-2-hydroxy-4-methylpentanoate

(S)-1-(benzyloxycarbonyl)-3-methylbuthyl 4'-octocxybiphenyl-4-carboxylate

Refernces