Monastrol

Base Information

Chemical Name:Monastrol
CAS No.:254753-54-3
Molecular Formula:C₁₄H₁₆N₂O₃S
Molecular Weight:292.359
Hs Code.:
NSC Number:716782
DSSTox Substance ID:DTXSID10388124,DTXSID501317756
Nikkaji Number:J1.229.496D
Wikipedia:Monastrol
Wikidata:Q6898425
Pharos Ligand ID:S7LS593LZTM7
ChEMBL ID:CHEMBL236789
Mol file:254753-54-3.mol

Synonyms:monastrol

Suppliers and Price of Monastrol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Monastrol
1mg
$ 75.00

Sigma-Aldrich
Monastrol ≥98% (HPLC), solid
5mg
$ 293.00

Sigma-Aldrich
Monastrol A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.
5mg
$ 281.20

Sigma-Aldrich
Monastrol ≥98% (HPLC), solid
1mg
$ 89.30

Sigma-Aldrich
Monastrol A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.
1mg
$ 85.65

Medical Isotopes, Inc.
Monastrol
25 mg
$ 1760.00

DC Chemicals
Monastrol
002
$ 950.00

Total 16 raw suppliers

Chemical Property of Monastrol

Chemical Property:

Vapor Pressure:2.13E-08mmHg at 25°C
Melting Point:185-185.9 °C(lit.)
Boiling Point:441.3°Cat760mmHg
PKA:9.63±0.10(Predicted)
Flash Point:220.7°C
PSA：102.68000
Density:1.34g/cm³
LogP:2.40570
Storage Temp.:2-8°C
Solubility.:DMSO: 100 mg/mL
XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:292.08816355
Heavy Atom Count:20
Complexity:436

Purity/Quality:

98%,99%, ^*data from raw suppliers

Monastrol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
Description Monastrol (254753-54-3) is a potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1?Does not affect other motor proteins or tubulin. Specifically inhibits the mitotic molecular motor kinesin Eg5, a motor protein required for spindle formation (IC50?= 14 μM).2?Mimics the effect of amyloid β on long term potentiation in a cellular model of learning and memory.3?Enhances regeneration of adult axons.4
Uses Inhibitor of mammalian cell mitosis. Monastrol has been used:to treat MDA-MB-231 cells as a non-microtubule-targeting agentas a antineoplastic agent, to treat mouse myeloma cell line SP 2/0, to induce apoptosis and to elucidate the role of metabotropic glutamate receptor 3 (Grm3) in apoptosisas an inhibitor of pteridine reductase in GFP-transfected promastigotes infected macrophages for flow cytometer-based growth inhibition assay and to evaluate anti-leishmanial activity of Leishmania donovani hamster model in vivo A cell-permeablesmall molecule inhibitor of the mitotic kinesin, Eg5, arrests cells in mitosis with monoastral spindles

Technology Process of Monastrol

There total 32 articles about Monastrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 141-97-9
ethyl acetoacetate

: 100-83-4
meta-hydroxybenzaldehyde

: 17356-08-0
thiourea

: 329689-23-8,254753-54-3,268739-54-4
monastrol

Guidance literature:: Wells-Dawson heteropolyacid catalyst; at 80 ℃; for 1.5h;
DOI:10.1080/00397910701572332

Reference yield: 98.0%

: 1243989-70-9
C₁₈H₂₂N₂O₄S

: 254753-54-3,268739-54-4
(S)-monastrol

Guidance literature:: With water; In dichloromethane; at 40 ℃; for 49h; pH=7; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;
DOI:10.1016/j.bmcl.2010.05.063