Pyridine, 1,2-dihydro-1-[(E)-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenyl methyl]-2-phenyl-3-[[tris(1-methylethyl)silyl]oxy]-, (2R)-

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Chemical Name:Pyridine, 1,2-dihydro-1-[(E)-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenyl methyl]-2-phenyl-3-[[tris(1-methylethyl)silyl]oxy]-, (2R)-
CAS No.:849774-32-9
Molecular Formula:C33H48N2O2Si
Molecular Weight:532.842
Hs Code.:

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Chemical Property of Pyridine, 1,2-dihydro-1-[(E)-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenyl methyl]-2-phenyl-3-[[tris(1-methylethyl)silyl]oxy]-, (2R)-

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Technology Process of Pyridine, 1,2-dihydro-1-[(E)-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenyl methyl]-2-phenyl-3-[[tris(1-methylethyl)silyl]oxy]-, (2R)-

There total 2 articles about Pyridine, 1,2-dihydro-1-[(E)-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenyl methyl]-2-phenyl-3-[[tris(1-methylethyl)silyl]oxy]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: phenylmagnesium bromide

: 87768-46-5
N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide

: 849774-31-8
3-[(triisopropylsilyl)oxy]pyridine

: 849774-32-9
N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-{(1E)-phenyl[(2R)-2-phenyl-3-[(triisopropylsilyl)oxy]pyridin-1(2H)-yl]methylene}amine

Guidance literature:: N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide; 3-[(triisopropylsilyl)oxy]pyridine; With trifluoromethylsulfonic anhydride; In dichloromethane; at -40 - 20 ℃;

phenylmagnesium bromide; In diethyl ether; dichloromethane; at -78 ℃; for 4h;
DOI:10.1021/jo048216x

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 849774-32-9
N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-{(1E)-phenyl[(2R)-2-phenyl-3-[(triisopropylsilyl)oxy]pyridin-1(2H)-yl]methylene}amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / imidazole / dimethylformamide / 0 - 20 °C

2.1: (Tf₂)O / CH₂Cl₂ / -40 - 20 °C

2.2: 57 percent / CH₂Cl₂; diethyl ether / 4 h / -78 °C

With 1H-imidazole; trifluoromethylsulfonic anhydride; In dichloromethane; N,N-dimethyl-formamide; 2.2: Grignard reaction;
DOI:10.1021/jo048216x