87768-46-5

Upstream product

• 149182-41-2 (S)-N-(1-hydroxy-3-methylbutan-2-yl)benzamide 
• 74-88-4 methyl iodide 
• 64715-88-4 (S)-2-amino-1-methoxy-3-methylbutane 
• 98-88-4 benzoyl chloride 
• 2026-48-4 (S)-valinol 
• 1185294-54-5 1-(1-methylethoxy)-3-phenyl-2-propylamine hydrochloride 

Downstream Products

• 849774-32-9 N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-{(1E)-phenyl[(2R)-2-phenyl-3-[(triisopropylsilyl)oxy]pyridin-1(2H)-yl]methylene}amine 
• 93-55-0 1-phenyl-propan-1-one 
• 1185294-54-5 1-(1-methylethoxy)-3-phenyl-2-propylamine hydrochloride 
• 386253-22-1 N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2R)-2-methylpyridin-1(2H)-yl](phenyl)methylene]amine 
• 386253-34-5 (S)-1-methoxy-3-methyl-N(phenyl((S)-2-phenylpyridin-1(2H)-yl)methylene)butan-2-amine 
• 386253-33-4 (E)-N-[(2S)-1-methoxy-3-methylbutan-2-yl]-1-[(2R)-2-ethylpyridin-1(2H)-yl]-1-phenylmethanimine 
• 399559-62-7 tert-butyl benzyl[(1S)-1-(hydroxymethyl)-2-methylpropyl]carbamate 
• 857900-04-0 (2R,3R,6R)-6-[12-(benzyloxy)dodecyl]-1-[(E)-{[(1S)-1-(methoxymethyl)-2-methylpropyl]imino} (phenyl)methyl]-2-methylpiperidin-3-ol 

Relevant academic research and scientific papers

Tf2O-Mediated Intermolecular Coupling of Secondary Amides with Enamines or Ketones: A Versatile and Direct Access to β-Enaminones

Based on the Tf2O-mediated intermolecular reaction of secondary amides with enamines derived from ketones, a novel approach to β-enaminones has been developed. The reaction is widely functional group tolerant and highly chemoselective. In the presence of 4 ? molecular sieves, the method can be extended to the one-pot condensation of secondary amides with ketones for NH β-enaminones synthesis.

Chemoselective Synthesis of α-Amino-α-cyanophosphonates by Reductive Gem-Cyanation-Phosphonylation of Secondary Amides

A novel approach to α-amino-α-cyanophosphonates has been developed. The method features a Tf2O-mediated reductive geminal cyanation/phosphonylation of secondary amides. Mild reaction conditions, high bond-forming efficiency, inexpensive readily available starting materials, and good to excellent yields with wide functional group compatibility constitute the main advantages of this method. The protocol can be run on a gram scale.