2,2,6,6-Tetramethylpiperidine hydrochloride

Base Information

• Chemical Name: 2,2,6,6-Tetramethylpiperidine hydrochloride
• CAS No.: 935-22-8
• Molecular Formula: C₉H₂₀N*Cl
• Molecular Weight: 177.717
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90239448
• Mol file: 935-22-8.mol

Synonyms:2,2,6,6-Tetramethylpiperidine hydrochloride;935-22-8;TP HCl;Piperidine, 2,2,6,6-tetramethyl-, hydrochloride;2,2,6,6-tetramethylpiperidine;hydrochloride;Tempidine;DTXSID90239448;LS-116193;FT-0691317;2,2,6,6-TETRAMETHYLPIPERIDINEHYDROCHLORIDE

Chemical Property of 2,2,6,6-Tetramethylpiperidine hydrochloride

Chemical Property:

• Vapor Pressure: 2.73mmHg at 25°C
• Melting Point: 299-301 °C(lit.)
• Boiling Point: 157.6°Cat760mmHg
• Flash Point: 24.4°C
• PSA: 12.03000
• Density: g/cm³
• LogP: 3.44790
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 177.1284273
• Heavy Atom Count: 11
• Complexity: 111

Purity/Quality:

98% (TLC) ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCCC(N1)(C)C)C.Cl

Technology Process of 2,2,6,6-Tetramethylpiperidine hydrochloride

There total 7 articles about 2,2,6,6-Tetramethylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2,6,6-tetramethyl-piperidine (768-66-1) → 2,2,6,6-Tetramethylpiperidiniumhydrochlorid (935-22-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

DOI:10.1002/anie.201507298

Reference yield: 48.0%

dichloro-(2,2,6,6,-tetramethylpiperidino)borane (79855-29-1) → 2,2,6,6-Tetramethylpiperidiniumhydrochlorid (935-22-8)

Guidance literature:

With Me₃Si-N(CH₃)-SO₂-N(CH₃)-SiMe₃; In toluene; for 10h; Heating;

Reference yield: 48.0%

Me3Si-N(CH3)-SO2-N(CH3)-SiMe3 (74669-28-6) + dichloro-(2,2,6,6,-tetramethylpiperidino)borane (79855-29-1) → 2,2,6,6-Tetramethylpiperidiniumhydrochlorid (935-22-8)

Guidance literature:

In toluene; byproducts: Me3SiCl; under protective gas; reflux of solution (10 h);; evapn. (vacuo); extn. (n-hexane/CH2Cl2); residue was recrystd. (CH2Cl2); elem. anal.; extract contains mixture of two B-compounds; (11)B-NMR;;

upstream raw materials:

dichloro-(2,2,6,6,-tetramethylpiperidino)borane

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

p-toluenesulfonyl chloride

Me₃Si-N(CH₃)-SO₂-N(CH₃)-SiMe₃