1H-Imidazole-4-carboxylic acid, 1-[2-(2-bromophenyl)ethyl]-, methyl ester

Base Information

Chemical Name:1H-Imidazole-4-carboxylic acid, 1-[2-(2-bromophenyl)ethyl]-, methyl ester
CAS No.:850008-77-4
Molecular Formula:C13H13BrN2O2
Molecular Weight:309.162
Hs Code.:

Synonyms:1-[2-(2-bromophenyl)ethyl]-1H-imidazole-4-carboxylic acid methyl ester;1-[2-(2-Bromo-phenyl)-ethyl]-1H-imidazole-4-carboxylic acid methyl ester;

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Chemical Property of 1H-Imidazole-4-carboxylic acid, 1-[2-(2-bromophenyl)ethyl]-, methyl ester

Chemical Property:

Boiling Point:463.5±30.0 °C(Predicted)
PSA：44.12000
Density:1.43±0.1 g/cm3(Predicted)
LogP:2.67490

Purity/Quality:

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Technology Process of 1H-Imidazole-4-carboxylic acid, 1-[2-(2-bromophenyl)ethyl]-, methyl ester

There total 4 articles about 1H-Imidazole-4-carboxylic acid, 1-[2-(2-bromophenyl)ethyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 2183-83-7
methanesulfonic acid 2-(2-bromophenyl)ethyl ester

: 17325-26-7
Methyl imidazole-4-carboxylate

: 850008-77-4
methyl 1-[2-(2-bromophenyl)ethyl]-1H-imidazole-4-carboxylate

: 850008-78-5
methyl 1-[2-(2-bromophenyl)ethyl]-1H-imidazole-5-carboxylate

Guidance literature:: Methyl imidazole-4-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; oil; at 80 ℃; for 1h;

methanesulfonic acid 2-(2-bromophenyl)ethyl ester; In N,N-dimethyl-formamide; oil; at 80 ℃; for 12h;

Reference yield: 43.0%

: 2183-83-7
methanesulfonic acid 2-(2-bromophenyl)ethyl ester

: 17325-26-7
Methyl imidazole-4-carboxylate

: 850008-77-4
methyl 1-[2-(2-bromophenyl)ethyl]-1H-imidazole-4-carboxylate

Guidance literature:: Methyl imidazole-4-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Inert atmosphere;

methanesulfonic acid 2-(2-bromophenyl)ethyl ester; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;
DOI:10.1055/s-0040-1708003

Reference yield:

: 1074-16-4
2-bromophenylethyl alcohol

: 850008-77-4
methyl 1-[2-(2-bromophenyl)ethyl]-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / toluene / 18 h / 20 °C

2: 50 percent / sodium hydride / dimethylformamide / 12 h / 80 °C

With sodium hydride; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2005.01.064