Technology Process of Benzo[b]thiophene-2-carboxamide,
5-[bis(phenylmethyl)amino]-N-hydroxy-
There total 4 articles about Benzo[b]thiophene-2-carboxamide,
5-[bis(phenylmethyl)amino]-N-hydroxy- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-dibenzylamino-benzo[b]thiophene-2-carboxylic acid ethyl ester;
With
hydroxylamine hydrochloride; sodium methylate;
In
methanol; N,N-dimethyl-formamide;
for 16h;
With
hydrogenchloride;
In
methanol; water; N,N-dimethyl-formamide;
pH=6;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h / 20 °C / 760.05 Torr
2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C
3.1: hydroxylamine hydrochloride; sodium methylate / methanol; N,N-dimethyl-formamide / 16 h
3.2: pH 6
With
hydroxylamine hydrochloride; hydrogen; sodium methylate; potassium carbonate;
palladium 10% on activated carbon;
In
methanol; ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h / 20 °C / 760.05 Torr
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C
4.1: hydroxylamine hydrochloride; sodium methylate / methanol; N,N-dimethyl-formamide / 16 h
4.2: pH 6
With
hydroxylamine hydrochloride; hydrogen; sodium methylate; potassium carbonate;
palladium 10% on activated carbon;
In
methanol; ethanol; N,N-dimethyl-formamide;