Prothipendyl

Base Information

• Chemical Name: Prothipendyl
• CAS No.: 303-69-5
• Molecular Formula: C16H19 N3 S
• Molecular Weight: 285.44
• Hs Code.: 2934999090
• European Community (EC) Number: 608-469-9
• UNII: 5O6VWA87VA
• DSSTox Substance ID: DTXSID50184389
• Nikkaji Number: J5.491G
• Wikipedia: Prothipendyl
• Wikidata: Q903551
• NCI Thesaurus Code: C84124
• Metabolomics Workbench ID: 153841
• ChEMBL ID: CHEMBL2111030
• Mol file: 303-69-5.mol

Synonyms:Dominal;prothipendyl;prothipendyl hydrochloride

Chemical Property of Prothipendyl

Chemical Property:

• Vapor Pressure: 1.26E-07mmHg at 25°C
• Melting Point: 25°C
• Refractive Index: 1.5605 (estimate)
• Boiling Point: 430.8°Cat760mmHg
• PKA: 9.37±0.28(Predicted)
• Flash Point: 214.3°C
• PSA: 44.67000
• Density: 1.168g/cm³
• LogP: 3.70100
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 285.12996879
• Heavy Atom Count: 20
• Complexity: 310

Purity/Quality:

99.9% ^*data from raw suppliers

PROTHIPENDYL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1N=CC=C3
• Recent ClinicalTrials: Pharmacovigilance in Gerontopsychiatric Patients

Technology Process of Prothipendyl

There total 8 articles about Prothipendyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-azaphenothiazine (261-96-1) + 3-(Dimethylamino)propyl chloride (109-54-6) → prothipendyl (303-69-5)

Guidance literature:

With sodium amide; xylene;

DOI:10.1021/ja01540a035

Reference yield:

10-acetyl-10H-benzo[b]pyrido[2,3-e][1,4]thiazine (95873-97-5) → prothipendyl (303-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic HCl

2: NaNH₂; xylene

With hydrogenchloride; sodium amide; xylene;

DOI:10.1021/ja01540a035

Reference yield:

2-<(2-aminophenyl)thio>-3-nitropyridine (92316-06-8) → prothipendyl (303-69-5)

Guidance literature:

Multi-step reaction with 4 steps

2: aq.-ethanolic KOH

3: aq.-ethanolic HCl

4: NaNH₂; xylene

With hydrogenchloride; potassium hydroxide; sodium amide; xylene;

DOI:10.1021/ja01540a035

upstream raw materials:

1-azaphenothiazine

3-(Dimethylamino)propyl chloride

dimethyl amine

1.3-chlorobromopropane

Downstream raw materials:

2-chloro-3-(dimethylamino)naphthalene-1,4-dione