Dimethylamine

Base Information

• Chemical Name: Dimethylamine
• CAS No.: 124-40-3
• Molecular Formula: C2H7N
• Molecular Weight: 45.0843
• Hs Code.: 2921.11 Oral rat LD50: 90 mg/kg
• European Community (EC) Number: 204-697-4
• ICSC Number: 0260
• NSC Number: 187661,8650
• UN Number: 1032,1160
• UNII: ARQ8157E0Q
• DSSTox Substance ID: DTXSID5024057
• Nikkaji Number: J1.943.801E,J2.933E
• Wikipedia: Dimethylamine
• Wikidata: Q408022,Q83034465
• RXCUI: 1745413
• Metabolomics Workbench ID: 37068
• ChEMBL ID: CHEMBL120433
• Mol file: 124-40-3.mol

Synonyms:dimethylamine;dimethylamine hydrochloride;dimethylamine monosulfate;dimethylamine nitrate;dimethylamine perchlorate;dimethylamine phosphate (3:1);dimethylamine sulfate;dimethylamine sulfate (1:1);dimethylamine, conjugate acid;dimethylammonium chloride;dimethylammonium formate

Chemical Property of Dimethylamine

Chemical Property:

• Appearance/Colour: colourless compressed liquefied gas
• Vapor Pressure: 3.35E-05mmHg at 25°C
• Melting Point: -93 °C
• Refractive Index: 1.347
• Boiling Point: 6.1 °C at 760 mmHg
• Flash Point: 60°F
• PSA: 12.03000
• Density: 0.68 g/cm³
• LogP: 0.22650
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 45.057849228
• Heavy Atom Count: 3
• Complexity: 2.8
• Transport DOT Label: Flammable Gas

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F:Flammable;;
• Statements: R12:; R20:; R37/38:; R41:
• Safety Statements: S16:; S26:; S29:

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CNC
• Recent ClinicalTrials: A Ph1 Study in Healthy Male Japanese and Caucasian After Single and Multiple Doses of D5884(Omega-3-carboxylic Acids)
• Inhalation Risk: On loss of containment, a harmful concentration of this gas in the air will be reached very quickly, especially in confined spaces.
• Effects of Short Term Exposure: The substance is corrosive to the eyes. The substance is irritating to the respiratory tract and skin. Exposure could cause visual disturbances. Inhalation of high levels may cause lung oedema. Rapid evaporation of the liquid may cause frostbite.
• Effects of Long Term Exposure: Repeated or prolonged contact may cause skin sensitization.

Technology Process of Dimethylamine

There total 858 articles about Dimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(+/-)-erythro-methylephedrine (552-79-4,1201-56-5,14222-20-9,17605-71-9,39263-91-7,42151-56-4,51018-28-1,62560-55-8,87040-40-2) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + ephedrine (90-81-3,90-82-4,299-42-3,321-97-1,321-98-2,4125-58-0,34783-90-9,38732-95-5,53214-57-6,7009-81-6,90-83-5,6912-63-6) + benzaldehyde (100-52-7) + acetaldehyde (75-07-0,9002-91-9) + dimethyl amine (124-40-3)

Guidance literature:

With water; at 25 ℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;

Reference yield: 88.0%

N-methylisoephedrine (160745-23-3) → 2-hydroxy-1-phenylpropylamine (52500-61-5) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + benzaldehyde (100-52-7) + acetaldehyde (75-07-0,9002-91-9) + dimethyl amine (124-40-3) + methylamine (74-89-5)

Guidance literature:

With water; at 25 ℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;

Reference yield: 79.0%

(+/-)-erythro-methoxyephedrine (2226-33-7,46288-71-5,79297-94-2,79297-97-5,82950-54-7,133161-06-5) → methanol (67-56-1) + ephedrine (90-81-3,90-82-4,299-42-3,321-97-1,321-98-2,4125-58-0,34783-90-9,38732-95-5,53214-57-6,7009-81-6,90-83-5,6912-63-6) + benzaldehyde (100-52-7) + acetaldehyde (75-07-0,9002-91-9) + dimethyl amine (124-40-3) + methylamine (74-89-5)

Guidance literature:

With water; at 25 ℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;

upstream raw materials:

pyrrolidine

N′,N″-diisopropyl-N,N-dimethyl guanidine

piperidine

1-indoline

Downstream raw materials:

dimethyl-(2-hydroxy-pentyl)-amine

dimethylamino-2-methyl-2-butanol

1,3-bis-(dimethylamino)propan-2-ol

(±)-N,N-dimethyl-trans-1,2-diaminocyclohexane

Refernces

• 1、 Korobeinichev,Shmakov,Chernov,Kosinova,Sulyaeva,Kuznetsov. "Thermal decomposition of trimethylamine borane as a precursor to nanocrystalline CVD BC x N y films". . p. 1199 - 1204. Retrieved 2011.
• 2、 Ayhan, Ozan,Eckert, Thomas,Plamper, Felix A.,Helten, Holger. "Poly(iminoborane)s: An Elusive Class of Main-Group Polymers?". . p. 13321 - 13325. Retrieved 2016.
• 3、 Beydoun, Kassem,Thenert, Katharina,Streng, Emilia S.,Brosinski, Sandra,Leitner, Walter,Klankermayer, Jürgen. "Selective Synthesis of Trimethylamine by Catalytic N-Methylation of Ammonia and Ammonium Chloride by utilizing Carbon Dioxide and Molecular Hydrogen". . p. 135 - 138. Retrieved 2016.
• 4、 Lewis, Charles A.,Wolfenden, Richard. "The nonenzymatic decomposition of guanidines and amidines". . p. 130 - 136. Retrieved 2014.
• 5、 Ferdous,Waigh. "Application of the WATR technique for water suppression in 1H NMR spectroscopy in determination of the kinetics of hydrolysis of neostigmine bromide in aqueous solution". . p. 559 - 562. Retrieved 1993.
• 6、 Brown, H. C.,Bartholomay, H.,Taylor, M. D.. "". . p. 435 - 442. Retrieved 1944.
• 7、 Miller et al.. "". . p. 2201,2203. Retrieved 1945.
• 8、 McCloskey,A.L. et al.. "". . p. 4750 - 4754. Retrieved 1961.
• 9、 Lamprecht, Zandria,Moeng, Mmushi M.,Liles, David C.,Lotz, Simon,Bezuidenhout, Daniela I.. "Thiophene site activation: Synthesis and structures of Fischer carbene complexes with 3,3′- and 2,3′-bithienyl substituents". . p. 193 - 207. Retrieved 2019.
• 10、 Cooper, William C.,Chilukoorie, Abhinay,Polam, Suhesh,Scott, Dane,Wiseman, Floyd. "A comparative study on the hydrolysis of acetic anhydride and N,N-dimethylformamide: Kinetic isotope effect, transition-state structure, polarity, and solvent effect". . . Retrieved 2017.