Technology Process of 2H-Pyran-2-one,
6-[(1E,3R,4R,6R)-4-[[(3,4-dimethoxyphenyl)methoxy]methoxy]-6-[[(1,1-
dimethylethyl)dimethylsilyl]oxy]-8-[dimethyl(phenylmethyl)silyl]-3-methyl-3
-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5,6-dihydro-, (6R)-
There total 17 articles about 2H-Pyran-2-one,
6-[(1E,3R,4R,6R)-4-[[(3,4-dimethoxyphenyl)methoxy]methoxy]-6-[[(1,1-
dimethylethyl)dimethylsilyl]oxy]-8-[dimethyl(phenylmethyl)silyl]-3-methyl-3
-[(triethylsilyl)oxy]-1-octen-7-ynyl]-5,6-dihydro-, (6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Grubbs catalyst first generation;
In
dichloromethane;
for 18h;
Heating;
DOI:10.1021/ja042435i
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 58 percent / (S,S)-2,6{[2-(Ph2(OH)C)pyrrolidin-1-yl]CH2}2-4MePhOH; Et2Zn; molecular sieves 4 Angstroem / tetrahydrofuran; hexane / 21 h / 20 °C
2.1: 88 percent / chiral Ru catalyst / propan-2-ol / 17.5 h / 20 °C
3.1: imidazole / dimethylformamide / 21 h / 20 °C
4.1: 8.52 g / CSA / acetone / 0.67 h / 20 °C
5.1: 97 percent / i-Pr2NEt; n-Bu4I / dimethylformamide / 22 h / 40 °C
6.1: allylmagnesium bromide / tetrahydrofuran / 0.33 h / 20 °C
6.2: 75 percent / isopropylmagnesium chloride; s-BuLi / tetrahydrofuran; cyclohexane / 3 h / -78 °C
7.1: 91 percent / aq. HF / acetonitrile; methanol / 4 h / 0 °C
8.1: 99 percent / Pr2NEt / CH2Cl2 / 2 h / 0 °C
9.1: 99 percent / i-Pr2NEt / CH2Cl2 / 0.25 h / 0 °C
10.1: 93 percent / first generation Grubbs catalyst / CH2Cl2 / 18 h / Heating
With
1H-imidazole; Grubbs catalyst first generation; dipropylethylamine; 4 A molecular sieve; chiral Ru catalyst; camphor-10-sulfonic acid; hydrogen fluoride; diethylzinc; N-ethyl-N,N-diisopropylamine; ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol); allylmagnesium bromide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; acetonitrile;
DOI:10.1021/ja042435i
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 88 percent / chiral Ru catalyst / propan-2-ol / 17.5 h / 20 °C
2.1: imidazole / dimethylformamide / 21 h / 20 °C
3.1: 8.52 g / CSA / acetone / 0.67 h / 20 °C
4.1: 97 percent / i-Pr2NEt; n-Bu4I / dimethylformamide / 22 h / 40 °C
5.1: allylmagnesium bromide / tetrahydrofuran / 0.33 h / 20 °C
5.2: 75 percent / isopropylmagnesium chloride; s-BuLi / tetrahydrofuran; cyclohexane / 3 h / -78 °C
6.1: 91 percent / aq. HF / acetonitrile; methanol / 4 h / 0 °C
7.1: 99 percent / Pr2NEt / CH2Cl2 / 2 h / 0 °C
8.1: 99 percent / i-Pr2NEt / CH2Cl2 / 0.25 h / 0 °C
9.1: 93 percent / first generation Grubbs catalyst / CH2Cl2 / 18 h / Heating
With
1H-imidazole; Grubbs catalyst first generation; dipropylethylamine; chiral Ru catalyst; camphor-10-sulfonic acid; hydrogen fluoride; N-ethyl-N,N-diisopropylamine; allylmagnesium bromide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; acetonitrile;
DOI:10.1021/ja042435i
