1-Piperazinecarboxylic acid, 4-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-(phenylmethoxy )ethyl]-3-oxo-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-(phenylmethoxy )ethyl]-3-oxo-, 1,1-dimethylethyl ester
CAS No.:850148-81-1
Molecular Formula:C25H42N2O5Si
Molecular Weight:478.704
Hs Code.:

1-Piperazinecarboxylic acid,
4-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-(phenylmethoxy
)ethyl]-3-oxo-, 1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of 1-Piperazinecarboxylic acid, 4-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-(phenylmethoxy )ethyl]-3-oxo-, 1,1-dimethylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-(phenylmethoxy )ethyl]-3-oxo-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperazinecarboxylic acid, 4-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-(phenylmethoxy )ethyl]-3-oxo-, 1,1-dimethylethyl ester

There total 3 articles about 1-Piperazinecarboxylic acid, 4-[(1S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-(phenylmethoxy )ethyl]-3-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026468-15-4
{2-[1-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylamino]-ethyl}-carbamic acid tert-butyl ester

: 13094-51-4
bromoacetic anhydride

: 850148-81-1
(1'S)-4-(tert-butoxycarbonyl)-1-[1'-phenylmethyloxymethyl-2'-[(tert-butyldimethylsilyl)oxy]ethyl]-2-oxopiperazine

Guidance literature:: {2-[1-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylamino]-ethyl}-carbamic acid tert-butyl ester; bromoacetic anhydride; With 4-methyl-morpholine; In dichloromethane;

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1039/b416162a

Reference yield:

: 850148-82-2
(2R)-6-(tert-butoxycarbonyl)-2-phenylmethyloxymethyl-3,6-diazahexan-1-ol

: 850148-81-1
(1'S)-4-(tert-butoxycarbonyl)-1-[1'-phenylmethyloxymethyl-2'-[(tert-butyldimethylsilyl)oxy]ethyl]-2-oxopiperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: imidazole / CH₂Cl₂

2.1: N-methylmorpholine / CH₂Cl₂

2.2: NaH / tetrahydrofuran / 5 h / 0 °C

With 4-methyl-morpholine; 1H-imidazole; In dichloromethane;
DOI:10.1039/b416162a

Reference yield:

: 67864-85-1
Boc-Gly-Ser(-CH₂-Ph)-OMe

: 850148-81-1
(1'S)-4-(tert-butoxycarbonyl)-1-[1'-phenylmethyloxymethyl-2'-[(tert-butyldimethylsilyl)oxy]ethyl]-2-oxopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / LiAlH₄ / tetrahydrofuran / 30 h / 20 °C

2.1: imidazole / CH₂Cl₂

3.1: N-methylmorpholine / CH₂Cl₂

3.2: NaH / tetrahydrofuran / 5 h / 0 °C

With 4-methyl-morpholine; 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b416162a