1-Piperazinecarboxylic acid, 4-[(1S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)ethyl]-3 -oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester, (2R)-

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[(1S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)ethyl]-3 -oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester, (2R)-
CAS No.:850148-94-6
Molecular Formula:C25H42N2O5Si
Molecular Weight:478.704
Hs Code.:

1-Piperazinecarboxylic acid,
4-[(1S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)ethyl]-3
-oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester, (2R)-

Synonyms:

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[(1S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)ethyl]-3 -oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester, (2R)-

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Technology Process of 1-Piperazinecarboxylic acid, 4-[(1S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)ethyl]-3 -oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester, (2R)-

There total 4 articles about 1-Piperazinecarboxylic acid, 4-[(1S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(hydroxymethyl)ethyl]-3 -oxo-2-(phenylmethyl)-, 1,1-dimethylethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850148-82-2
(2R)-6-(tert-butoxycarbonyl)-2-phenylmethyloxymethyl-3,6-diazahexan-1-ol

: 850148-94-6
(1'S,3R)-4-(tert-butoxycarbonyl)-1-[1'-hydroxymethyl-2'-[(tert-butyldimethylsilyl)oxy]ethyl]-3-phenylmethyl-2-oxopiperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: imidazole / CH₂Cl₂

2.1: N-methylmorpholine / CH₂Cl₂

2.2: NaH / tetrahydrofuran / 5 h / 0 °C

3.1: 90 percent / H₂ / Pd/C / methanol / 48 °C

4.1: LDA / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.25 h / -70 °C

4.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 5.5 h / -50 - -15 °C

With 4-methyl-morpholine; 1H-imidazole; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1039/b416162a

Reference yield:

: 1026468-15-4
{2-[1-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylamino]-ethyl}-carbamic acid tert-butyl ester

: 850148-94-6
(1'S,3R)-4-(tert-butoxycarbonyl)-1-[1'-hydroxymethyl-2'-[(tert-butyldimethylsilyl)oxy]ethyl]-3-phenylmethyl-2-oxopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-methylmorpholine / CH₂Cl₂

1.2: NaH / tetrahydrofuran / 5 h / 0 °C

2.1: 90 percent / H₂ / Pd/C / methanol / 48 °C

3.1: LDA / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.25 h / -70 °C

3.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 5.5 h / -50 - -15 °C

With 4-methyl-morpholine; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1039/b416162a

Reference yield:

: 850148-81-1
(1'S)-4-(tert-butoxycarbonyl)-1-[1'-phenylmethyloxymethyl-2'-[(tert-butyldimethylsilyl)oxy]ethyl]-2-oxopiperazine

: 850148-94-6
(1'S,3R)-4-(tert-butoxycarbonyl)-1-[1'-hydroxymethyl-2'-[(tert-butyldimethylsilyl)oxy]ethyl]-3-phenylmethyl-2-oxopiperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / H₂ / Pd/C / methanol / 48 °C

2.1: LDA / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.25 h / -70 °C

2.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 5.5 h / -50 - -15 °C

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
DOI:10.1039/b416162a