Desacetamidocolchicine

Base Information

Chemical Name:Desacetamidocolchicine
CAS No.:1420-08-2
Molecular Formula:C₂₀H₂₂O₅
Molecular Weight:342.392
Hs Code.:2914509090
UNII:SH73UDM5S9
DSSTox Substance ID:DTXSID10161919
Nikkaji Number:J71.592A
ChEMBL ID:CHEMBL4745498
Mol file:1420-08-2.mol

Synonyms:deacetamidocolchicine;desacetamidocolchicine

Suppliers and Price of Desacetamidocolchicine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
DESACETAMIDOCOLCHICINE 95.00%
5MG
$ 503.59

Total 6 raw suppliers

Chemical Property of Desacetamidocolchicine

Chemical Property:

Vapor Pressure:2.42E-14mmHg at 25°C
Boiling Point:599.7°Cat760mmHg
Flash Point:264.1°C
PSA：53.99000
Density:1.21g/cm³
LogP:3.23690
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:342.14672380
Heavy Atom Count:25
Complexity:603

Purity/Quality:

99% ^*data from raw suppliers

DESACETAMIDOCOLCHICINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C2C(=CC1=O)CCCC3=CC(=C(C(=C32)OC)OC)OC

Technology Process of Desacetamidocolchicine

There total 11 articles about Desacetamidocolchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 5320-47-8
Desacetamido-colchicein

: 74-88-4
methyl iodide

: 1420-08-2
deacetamidocolchicine

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃;
DOI:10.1016/j.bmcl.2014.05.007

Reference yield:

: 10-hydroxy-1,2,3-trimethoxy-(12ac)-6,7,10,11,12,12a-hexahydro-5H-7ar,10c-epoxido-benzo[a]heptalen-9-one

: 1420-08-2
deacetamidocolchicine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; benzene / Erwaermen des Reaktionsprodukts mit N-Brom-succinimid in CHCl₃

2: methanol; diethyl ether

With methanol; diethyl ether; toluene-4-sulfonic acid; benzene;
DOI:10.1021/ja01532a070

Reference yield:

: 3476-63-9
Eschenmoser's α-pyrone

: 1420-08-2
deacetamidocolchicine

Guidance literature:: Multi-step reaction with 6 steps

1: benzene / 70 °C

2: 70 percent / HOAc / tetrahydrofuran; H₂O / 3.5 h / 100 °C

3: 100 percent / toluene / 1.5 h / 110 °C

4: 53 percent / NH₂NH₂ / ethanol / 6 h / 0 - 25 °C

5: 100 percent / 2N KOH / ethanol / 21 h / 100 °C

6: methanol; tetrahydrofuran

With potassium hydroxide; acetic acid; hydrazine; In tetrahydrofuran; methanol; ethanol; water; toluene; benzene;
DOI:10.1021/jo00218a042