Technology Process of 5-(6,7-dimethoxyquinolin-3-yl)-2,3-dimethoxyphenyl trifluoromethanesulfonate
There total 6 articles about 5-(6,7-dimethoxyquinolin-3-yl)-2,3-dimethoxyphenyl trifluoromethanesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at -78 - 0 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / ethanol; water / 12 h / Inert atmosphere; Reflux
1.2: pH 9
2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere
3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 20 - 60 °C / 760.05 Torr
4.1: triethylamine / dichloromethane / -78 - 0 °C / Inert atmosphere
With
hydrogenchloride; hydrogen; potassium carbonate; acetic acid; triethylamine;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; ethanol; dichloromethane; water;
2.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere
2: hydrogen; acetic acid / palladium 10% on activated carbon / 20 - 60 °C / 760.05 Torr
3: triethylamine / dichloromethane / -78 - 0 °C / Inert atmosphere
With
hydrogen; potassium carbonate; acetic acid; triethylamine;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; dichloromethane; water;
1: Suzuki Coupling;
