Technology Process of 2H-1-Benzopyran-3-ol,
2-[3,4-bis(phenylmethoxy)phenyl]-3,4-dihydro-5,7-bis(phenylmethoxy)-8
-(phenylmethyl)-, (2S,3R)-
There total 6 articles about 2H-1-Benzopyran-3-ol,
2-[3,4-bis(phenylmethoxy)phenyl]-3,4-dihydro-5,7-bis(phenylmethoxy)-8
-(phenylmethyl)-, (2S,3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1R,2R)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propane-1,2-diol;
With
pyridinium p-toluenesulfonate; orthoformic acid triethyl ester;
In
1,2-dichloro-ethane;
at 55 ℃;
for 5h;
With
potassium carbonate;
In
methanol; 1,2-dimethoxyethane;
at 20 ℃;
DOI:10.1016/j.bmc.2004.12.056
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 46 percent / H2SO4; SiO2 / CH2Cl2 / 20 °C
2.1: imidazole / 72 h / 20 °C
3.1: AD-mix-β; methanesulfonamide / 0 °C
4.1: 2.4 g / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 20 °C
5.1: triethyl orthoformate; PPTS / 1,2-dichloro-ethane / 5 h / 55 °C
5.2: 77 percent / K2CO3 / 1,2-dimethoxy-ethane; methanol / 20 °C
With
1H-imidazole; methanesulfonamide; AD-mix-β; sulfuric acid; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; silica gel; orthoformic acid triethyl ester;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
1.1: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2004.12.056
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: imidazole / 72 h / 20 °C
2.1: AD-mix-β; methanesulfonamide / 0 °C
3.1: 2.4 g / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 20 °C
4.1: triethyl orthoformate; PPTS / 1,2-dichloro-ethane / 5 h / 55 °C
4.2: 77 percent / K2CO3 / 1,2-dimethoxy-ethane; methanol / 20 °C
With
1H-imidazole; methanesulfonamide; AD-mix-β; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; orthoformic acid triethyl ester;
In
tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2004.12.056
