(E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene

Base Information

Chemical Name:(E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene
CAS No.:850307-79-8
Molecular Formula:C₅₀H₄₄O₅
Molecular Weight:724.896
Hs Code.:

Synonyms:(E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene

Suppliers and Price of (E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene

There total 2 articles about (E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 850307-78-7
2-benzyl-3,5-bis(benzyloxy)phenol

: 362632-29-9
(E)-3-(3,4-bis(benzyloxy)phenyl)prop-2-en-1-ol

: 850307-79-8
(E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene

Guidance literature:: With sulfuric acid; silica gel; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2004.12.056

Reference yield:

: 59434-20-7
1,3,5-tri-O-benzylphloroglucinol

: 850307-79-8
(E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene

Guidance literature:: Multi-step reaction with 2 steps

1: 16 percent / butanethiol; sodium hydride / dimethylformamide / 1.5 h / 150 °C

2: 46 percent / H₂SO₄; SiO₂ / CH₂Cl₂ / 20 °C

With n-butanethiol; sulfuric acid; silica gel; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; 2: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2004.12.056

Reference yield:

: 850307-79-8
(E)-3-[2,4-bis(benzyloxy)-5-benzyl-6-hydroxyphenyl]-1-[3,4-bis(benzyloxy)phenyl]propene

: 3,4,5-Trihydroxy-benzoic acid (2S,3R)-8-benzyl-2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: imidazole / 72 h / 20 °C

2.1: AD-mix-β; methanesulfonamide / 0 °C

3.1: 2.4 g / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 20 °C

4.1: triethyl orthoformate; PPTS / 1,2-dichloro-ethane / 5 h / 55 °C

4.2: 77 percent / K₂CO₃ / 1,2-dimethoxy-ethane; methanol / 20 °C

5.1: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h / Heating

5.2: 90 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 °C

6.1: 91 percent / H₂ / Pd(OH)2/C / tetrahydrofuran; methanol / 6 h / 20 °C

With 1H-imidazole; oxalyl dichloride; methanesulfonamide; AD-mix-β; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; orthoformic acid triethyl ester; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.12.056