Benzamide, N-[3-[1,2-dihydro-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]- 2-oxo-1,6-naphthyridin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)-

Base Information

Chemical Name:Benzamide, N-[3-[1,2-dihydro-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]- 2-oxo-1,6-naphthyridin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)-
CAS No.:850450-21-4
Molecular Formula:C35H33F3N6O2
Molecular Weight:626.681
Hs Code.:

Benzamide,
N-[3-[1,2-dihydro-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-
2-oxo-1,6-naphthyridin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, N-[3-[1,2-dihydro-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]- 2-oxo-1,6-naphthyridin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)-

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Technology Process of Benzamide, N-[3-[1,2-dihydro-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]- 2-oxo-1,6-naphthyridin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)-

There total 15 articles about Benzamide, N-[3-[1,2-dihydro-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]- 2-oxo-1,6-naphthyridin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850451-78-4
N-[3-(7-chloro-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-4-methyl-phenyl]-3-trifluoromethyl-benzamide

: 148546-99-0
3-(4-methylpiperazin-1-yl)aniline

: 850450-21-4
N-(4-methyl-3-{1-methyl-7-[3-(4-methyl-piperazin-1-y)-phenylamino]-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl}-phenyl)-3-trifluoromethyl-benzamide

Guidance literature:: With potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 14h;

Reference yield:

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 850450-21-4
N-(4-methyl-3-{1-methyl-7-[3-(4-methyl-piperazin-1-y)-phenylamino]-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl}-phenyl)-3-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

3: potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C

With potassium tert-butylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6975-44-6
4,6-dihydroxynicotinic acid ethyl ester

: 850450-21-4
N-(4-methyl-3-{1-methyl-7-[3-(4-methyl-piperazin-1-y)-phenylamino]-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl}-phenyl)-3-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: trichlorophosphate / 2 h / 110 °C

2: acetonitrile / 2.5 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 78 °C

4: manganese(IV) oxide / dichloromethane / 2 h / 20 °C

5: sodium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

7: potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium tert-butylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;