850451-78-4

Basic information

• Product Name: Benzamide, N-[3-(7-chloro-1,2-dihydro-1-methyl-2-oxo-1,6-naphthyridin-3-yl)-4-meth ylphenyl]-3-(trifluoromethyl)-
• CAS NO: 850451-78-4
• Molecular Formula: C24H17ClF3N3O2
• Molecular Weight: 471.866
• Mol File: 850451-78-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[3-(7-chloro-1,2-dihydro-1-methyl-2-oxo-1,6-naphthyridin-3-yl)-4-meth ylphenyl]-3-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[3-(7-chloro-1,2-dihydro-1-methyl-2-oxo-1,6-naphthyridin-3-yl)-4-meth ylphenyl]-3-(trifluoromethyl)-(850451-78-4)
• EPA Substance Registry System: Benzamide, N-[3-(7-chloro-1,2-dihydro-1-methyl-2-oxo-1,6-naphthyridin-3-yl)-4-meth ylphenyl]-3-(trifluoromethyl)-(850451-78-4)

Safety Data

• Hazardous Substances Data: 850451-78-4(Hazardous Substances Data)

Upstream product

• 850451-77-3 3-(5-amino-2-methylphenyl)-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 287119-83-9 2-(2-Methyl-5-nitrophenyl)acetic acid 
• 287119-84-0 2-methyl-5-nitrophenylacetic acid methyl ester 
• 1975-52-6 5-nitro-o-toluic acid 
• 22474-47-1 (2-methyl-5-nitro-7-phenyl)methanol 
• 409082-10-6 (2-methyl-5-nitrophenyl)-methyl methylsulfonate 
• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 
• 40296-46-6 ethyl 4,6-dichloronicotinate 
• 409082-11-7 2-(2-methyl-5-nitrophenyl)acetonitrile 

Downstream Products

• 1021531-58-7 N-[4-methyl-3-(1-methyl-2-oxo-(E)-7-propenyl-1,2-dihydro-[1,6]naphthyridin-3-yl)-phenyl]-3-trifluoromethyl-benzamide 
• 850451-23-9 N-[3-(7-benzylamino-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-4-methyl-phenyl]-3-trifluoromethyl-benzamide 
• 850450-17-8 N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide 
• 850450-20-3 N-{3-[7-(3-dimethylaminomethyl-phenylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide 
• 850450-21-4 N-(4-methyl-3-{1-methyl-7-[3-(4-methyl-piperazin-1-y)-phenylamino]-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl}-phenyl)-3-trifluoromethyl-benzamide 
• 850450-18-9 N-[3-(7-ethylamino-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-4-methyl-phenyl]3-trifluoromethyl-benzamide 
• 850450-22-5 N-[3-(7-amino-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-4-methyl-phenyl]-3-trifluoromethyl-benzamide 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR MODULATING C-KIT AND PDGFR RECEPTORS

The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFR , PDGFR , CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGF , SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2 , BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.