12-Hydroxyicosa-5,8,10,14-tetraenoic acid

Base Information

Chemical Name:12-Hydroxyicosa-5,8,10,14-tetraenoic acid
CAS No.:59985-28-3
Molecular Formula:C₂₀H₃₂O₃
Molecular Weight:320.472
Hs Code.:
DSSTox Substance ID:DTXSID30869349
Mol file:59985-28-3.mol

Synonyms:12 S Hydroxyeicosatetraenoic Acid;12-HETE;12-Hydroxy-5,8,10,14-eicosatetraenoic Acid;12-R-HETE;12-S-HETE;12-S-Hydroxyeicosatetraenoic Acid;Acid, 12-S-Hydroxyeicosatetraenoic

Suppliers and Price of 12-Hydroxyicosa-5,8,10,14-tetraenoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 12-Hydroxyicosa-5,8,10,14-tetraenoic acid

Chemical Property:

Vapor Pressure:1.48E-11mmHg at 25°C
Boiling Point:487.7°C at 760 mmHg
Flash Point:262.8°C
Density:0.984g/cm³
XLogP3:5.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:14
Exact Mass:320.23514488
Heavy Atom Count:23
Complexity:392

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)O

Technology Process of 12-Hydroxyicosa-5,8,10,14-tetraenoic acid

There total 107 articles about 12-Hydroxyicosa-5,8,10,14-tetraenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 98678-66-1
(5Z,8Z,10E,14Z)-12-Acetoxy-icosa-5,8,10,14-tetraenoic acid methyl ester

: 71030-37-0,59985-28-3
12-Hydroxyeicosatetraenoic acid

Guidance literature:: With lithium hydroxide; In water; isopropyl alcohol;
DOI:10.1021/jo00222a054

Reference yield:

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 54397-85-2
thromboxane B₂

: 363-24-6
dinoprostone

: 54397-83-0,59985-28-3
12-hydroxyeicosatetraenoic acid

Guidance literature:: With microsomes of mutton vesicular glands; oxygen; In octane; water; at 25 ℃; for 1h; Product distribution; potassium phosphate buffer (pH 7.4) presence, n-octane absence;

Reference yield:

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 54397-83-0,59985-28-3
12-hydroxyeicosatetraenoic acid

: 82337-46-0
(R)-12-HETE

: 98462-03-4,79495-84-4
8(S)-hydroxyeicosatetraenoic acid

: 105500-09-2,79495-84-4
(8R)-hydroxyeicosatetraenoic acid

: 73347-43-0,73804-65-6
(R)-11-hydroxy-eicosa-5,8,12,14-tetraenoic acid

: 54845-95-3,73945-47-8,83603-31-0
icomucret

: 73945-47-8,83603-31-0
15(R)-HETE

: 54886-50-9,73804-65-6
(S)-11-hydroxy-eicosa-5,8,12,14-tetraenoic acid

Guidance literature:: all cis 5,8,11,14-eicosatetraenoic acid; With 8R-lipoxygenase A₅₈₉M mutant; sodium chloride; calcium chloride; In ethanol; at 20 ℃; pH=8; Enzymatic reaction;

With triphenylphosphine; In methanol; at 20 ℃; for 0.5h; Reagent/catalyst; Kinetics;
DOI:10.1074/jbc.M114.599662