Synonyms:tris(diethylamino)phosphine
98% *data from raw suppliers
Tris(diethylamino)phosphine *data from reagent suppliers
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There total 58 articles about Tris(diethylamino)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 94.0%
Reference yield: 82.0%
Reference yield: 80.0%
The study investigates the major malodorous component from the anal gland secretion of the male stoat (Mustela erminea). Through gas chromatographic analysis of a diethyl ether extract of the viscous yellow fluid from the anal glands, four volatile components were identified, with 2-propylthietane being the major and most volatile one (50%). The chemical structure of 2-propylthietane was determined based on its mass spectral data (m/e 116,101,87,82,74,73,69,67) and proton magnetic resonance (p.m.r.) spectrum, which showed a substituted thietane with a tertiary hydrogen adjacent to the sulphur atom and four other hydrogens on the ring. The compound was synthesized by desulphurisation of 3-propyl-1,2-dithiolane with tris(diethylamino) phosphine, and the mass spectrum, retention times, and p.m.r. spectra of the synthetic compound matched those of the natural substance. The study also mentions that the sulphur-containing constituents of the anal gland secretion from the mink are likely derived from an isoprenoid biosynthesis pathway, but 2-propylthietane from the stoat does not appear to be so derived. The nature of the remaining components and those from the female stoat are still under investigation.
This study focuses on the synthesis of ring A, a cyclic sulide peptide part containing dehydroalanine residues, in the peptide antibiotic nisin. The researchers employed two novel procedures: first, they derived a sulfide ring from a cyclic disulfide peptide through desulfurization with tris(diethylamino)phosphine (P(Et3N)3); second, they developed a simple and convenient method for preparing dehydroalanyl residues via Hofmann degradation of 2,3-diaminopropionyl residues in the presence of a sulfide linkage. The study successfully synthesized ring A, addressing challenges such as the introduction of dehydroamino acid residues and the formation of the sulfide ring. The synthesized ring A was confirmed through various analytical techniques, including NMR, FD-MS, and amino acid analysis, demonstrating the effectiveness of the new methods in synthesizing complex natural products like nisin.
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